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石榴提取物可降低良性前列腺增生大鼠前列腺重量并抑制前列腺细胞增殖。

Seoritae extract reduces prostate weight and suppresses prostate cell proliferation in a rat model of benign prostate hyperplasia.

机构信息

Department of Urology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-Gu, Seoul 137-701, Republic of Korea.

Korea Bio Medical Science Institute, Prime Tower 1st Floor Sinmunno 2-ga, Jongno-gu, Seoul 110-062, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2014;2014:475876. doi: 10.1155/2014/475876. Epub 2014 Feb 19.

DOI:10.1155/2014/475876
PMID:24701239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3950473/
Abstract

Seoritae is a type of black soybean that is known to have health-promoting effects due to its high isoflavone and anthocyanin contents. We evaluated whether Seoritae extract (SE) had beneficial effects on the reduction of prostate weight in a rat model of benign prostatic hyperplasia (BPH). BPH was induced by intramuscular injections of testosterone enanthate once a week for 5 weeks in Sprague-Dawley rats, and rats were treated with or without daily oral doses of SE during BPH induction. After 5 weeks, the oxidative stress (superoxide dismutase and 8-hydroxy-2-deoxyguanosine), apoptosis (caspase-3), and activity of 5-alpha reductase were evaluated in the serum and prostate. The SE treatment group showed a significant decrease in prostate weight, oxidative stress, apoptosis, and 5-alpha reductase activity compared to the nontreated BPH group. These results show that SE is effective in decreasing the weight and proliferation of the prostate, and suggest that SE may be an effective treatment for BPH.

摘要

黑大豆是一种具有促进健康作用的大豆，其异黄酮和花青素含量很高。我们评估了黑大豆提取物（SE）对良性前列腺增生（BPH）大鼠模型前列腺重量减轻是否有有益作用。BPH 通过每周一次肌肉注射庚酸睾酮诱导 5 周，在 BPH 诱导期间，大鼠接受或不接受 SE 的每日口服剂量治疗。5 周后，评估血清和前列腺中的氧化应激（超氧化物歧化酶和 8-羟基-2-脱氧鸟苷）、细胞凋亡（半胱天冬酶-3）和 5-α还原酶活性。与未治疗的 BPH 组相比，SE 治疗组的前列腺重量、氧化应激、细胞凋亡和 5-α还原酶活性显著降低。这些结果表明 SE 可有效减轻前列腺的重量和增殖，提示 SE 可能是 BPH 的有效治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cec/3950473/2c03dc87c801/ECAM2014-475876.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cec/3950473/890a0a669a80/ECAM2014-475876.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cec/3950473/2c03dc87c801/ECAM2014-475876.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cec/3950473/890a0a669a80/ECAM2014-475876.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cec/3950473/2c03dc87c801/ECAM2014-475876.002.jpg

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