Dosi Rupal, Bhatt Nikita, Shah Priyanki, Patell Rushad
Professor, Department of Medicine, Medical College Baroda, Gujrat, India .
Intern, Department of Medicine, Medical College Baroda, Gujrat, India .
J Clin Diagn Res. 2014 Feb;8(2):62-4. doi: 10.7860/JCDR/2014/6457.4009. Epub 2014 Feb 3.
The aim of the study was to study the abnormalities in the cardiovascular profile in postmenopausal Indian women and to compare the same with the cardiovascular profile of pre menopausal Indian women belonging to the same age group; taken as controls. The goal was to throw some light on the cardiovascular risk in postmenopausal women of the Indian population as this population is thought to be at higher risk than their western counterparts and significant studies of the same kind in this population have been few.
A cross-sectional comparative study on 100 women who were either postmenopausal or premenopausal and were between the age group of 40 to 55 years was carried out over a period of ten months at our hospital. The variations in the cardiovascular profile between both groups were studied. All the women were subjected to a detailed history, thorough examination, investigations and imaging studies.
The evaluation revealed that Coronary Artery Disease (CAD), hypertension, abnormal Body Mass Index (BMI) and abnormal Waist Hip Ratio (WHR) were significantly higher in the postmenopausal group as compared to the premenopausal group. The post menopausal women had significantly higher prevalence of abnormal lipid profiles as compared to their premenopausal counterparts. The postmenopausal women with a normal lipid profile also had increased prevalence of CAD and SAHT, which emphasizes the non-lipid cardiovascular benefits of estrogen.
Thus, we can conclude that cardiovascular disease was more common in postmenopausal women of age group 40-55 years as compared to those not yet achieved menopause in a population of western Indian women. And this risk was significantly associated with central obesity, an abnormal lipid profile and the postmenopausal state in itself.
本研究旨在探讨绝经后印度女性心血管状况的异常情况，并将其与同年龄组的绝经前印度女性的心血管状况进行比较，后者作为对照。目的是揭示印度人群中绝经后女性的心血管风险，因为该人群被认为比西方同龄人面临更高的风险，而针对该人群的同类重要研究较少。
在我院进行了一项为期十个月的横断面比较研究，研究对象为100名年龄在40至55岁之间的绝经后或绝经前女性。研究了两组之间心血管状况的差异。所有女性均接受了详细的病史询问、全面检查、调查和影像学检查。
评估显示，与绝经前组相比，绝经后组的冠状动脉疾病（CAD）、高血压、异常体重指数（BMI）和异常腰臀比（WHR）显著更高。与绝经前女性相比，绝经后女性脂质异常的患病率显著更高。脂质状况正常的绝经后女性CAD和SAHT的患病率也有所增加，这强调了雌激素对心血管的非脂质益处。
因此，我们可以得出结论，在西印度女性人群中，40 - 55岁年龄组的绝经后女性心血管疾病比未绝经女性更为常见。而且这种风险与中心性肥胖、脂质异常以及绝经后状态本身显著相关。
