艾蒿叶对雌性Wistar大鼠的抗生育活性。
Antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
作者信息
Shaik Afsar, Kanhere Rupesh S, Cuddapah Rajaram, Nelson Kumar S, Vara Prasanth Reddy, Sibyala Saisaran
机构信息
Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
出版信息
Chin J Nat Med. 2014 Mar;12(3):180-5. doi: 10.1016/S1875-5364(14)60030-3.
AIM
To evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
METHOD
The plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 mg·kg⁻¹, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats.
RESULTS
The data presented in this study demonstrate the antifertility potential of Artemisia vulgaris methanolic leaf extract, which shows a strong and significant decrease in implant formation (100%), and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats. These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity.
CONCLUSION
The methanolic plant extract of A. vulgaris has antifertility activity.
目的
评估普通蒿叶片对雌性Wistar大鼠的抗生育活性。
方法
分别以300和600 mg·kg⁻¹两个剂量水平测试植物提取物对植入物形成的影响。对有效的甲醇植物提取物进一步研究其对去卵巢未成熟雌性Wistar大鼠的雌激素活性。
结果
本研究提供的数据表明普通蒿甲醇叶提取物具有抗生育潜力，其显示植入物形成显著且强烈减少（100%），并具有强烈的雌激素效应，导致去卵巢未成熟大鼠子宫重量显著增加。这些观察结果表明普通蒿叶的甲醇提取物具有强大的抗植入活性和雌激素活性。
结论
普通蒿的甲醇植物提取物具有抗生育活性。
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