Tafesse Geremew, Mekonnen Yalemtsehay, Makonnen Eyasu
Department of Biology, Faculty of Education, Dilla College of Teachers' Education and Health Sciences, Debub University, Dilla, Ethiopia.
Afr Health Sci. 2006 Jun;6(2):81-5. doi: 10.5555/afhs.2006.6.2.81.
Asparagus africanus is claimed to have use in reproductive related health problems in some areas of Ethiopia.
To study the potential antifertility effect of the aqueous and ethanol extracts of the leaves and roots of Asparagus africanus in rats.
Water and ethanol extracts were given by gavages to rats in the in vivo test at a dose of 300 mg/kg of body weight, and rat uterine tissue were used for the in vitro test at different concentrations.
The aqueous extracts of the leaves and the roots showed an anti-implantation activity of 70% and 77%, respectively, while the ethanol extracts of the leaves and roots showed 48% and 61%, respectively. The antifertility activities of the aqueous and ethanol extracts were 40% (for leaves), 60% (for roots) and 20% (for leaves), 40% (for roots), respectively. All the extracts have resulted in significant (P< 0.05) reduction in the number of implants as compared with their respective controls. Each extract potentiated acetylcholine induced uterine contractions in a concentration dependent manner significantly (P< 0.05).
The results obtained in this study suggest that the leaves and roots of this plant may possess hormonal properties that can modulate the reproductive function of the experimental rats.
在埃塞俄比亚的一些地区，人们称非洲天门冬对生殖相关的健康问题有疗效。
研究非洲天门冬叶和根的水提取物及乙醇提取物对大鼠的潜在抗生育作用。
在体内试验中，以300毫克/千克体重的剂量通过灌胃给予大鼠水提取物和乙醇提取物；在体外试验中，使用不同浓度的大鼠子宫组织。
叶和根的水提取物抗着床活性分别为70%和77%，而叶和根的乙醇提取物分别为48%和61%。水提取物和乙醇提取物的抗生育活性分别为40%（叶）、60%（根）和20%（叶）、40%（根）。与各自的对照组相比，所有提取物均使着床数量显著减少（P<0.05）。各提取物均以浓度依赖方式显著增强乙酰胆碱诱导的子宫收缩（P<0.05）。
本研究结果表明，该植物的叶和根可能具有调节实验大鼠生殖功能的激素特性。
