Department of Dermatology and Venereology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming, China.
Dermatol Ther. 2014 Mar-Apr;27(2):83-8. doi: 10.1111/dth.12060. Epub 2013 May 20.
Facial flat wart, caused by human papilloma virus type 3 and less often, type 10, 27, and 41, often brings many cosmetic problems to children and young adults. Considering the disturbing cosmetic problem, the treatment of facial flat wart is always frustrating and often unsuccessful, although there are many treatment modalities. Considering the possible serious side effects of 5-aminolevulinic acid photodynamic therapy (ALA-PDT), we designed step-up therapy of ALA-PDT on different clinical phases of facial flat wart. As a new protocol of ALA-PDT, we found the step-up therapy of ALA-PDT could also receive excellent effects with the lower side effects. Meanwhile, the tolerance of patients to ALA-PDT could improve with subsequent treatment sessions and escalating doses of ALA-PDT.
扁平疣，由人乳头瘤病毒 3 型引起，较少由 10、27 和 41 型引起，常给儿童和青年带来许多美容问题。考虑到令人困扰的美容问题，尽管有许多治疗方法，但扁平疣的治疗总是令人沮丧且常常不成功。鉴于 5-氨基酮戊酸光动力疗法 (ALA-PDT) 可能产生严重的副作用，我们设计了针对扁平疣不同临床阶段的 ALA-PDT 逐步治疗方案。作为 ALA-PDT 的新方案，我们发现逐步治疗 ALA-PDT 也可以在降低副作用的情况下获得良好的效果。同时，随着后续治疗和 ALA-PDT 递增剂量的增加，患者对 ALA-PDT 的耐受性也会提高。
