Wang Qian, Jiang Can, Liu Wei, Chen Jin, Lin Xinyu, Huang Xiangning, Duan Xiling
Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital - Chengdu, China.
School of Clinical Medicine, Southwest Medical University - Luzhou, China.
An Bras Dermatol. 2017 May-Jun;92(3):350-355. doi: 10.1590/abd1806-4841.20175543.
Photodynamic therapy with topical aminolevulinic acid (ALA-PDT) has been suggested to be effective in treatment of acne vulgaris. However, adverse events occur during and after treatment.
To compare the efficacy and tolerability of optical intra-tissue fiber irradiation (OFI) ALA-PDT versus traditional ALA-PDT in treatment of acne vulgaris in rabbit models.
Twenty-five rabbits of clean grade were used. Twenty rabbits were randomly selected to establish acne model and the other five were used as control. Rabbits in model group (40 ears) were further divided into four groups (10 ears/group): I, OFI-ALA-PDT with the head of optical fiber inserted into the target lesion (intra-tissue); II, traditional ALA-PDT group; III, OFI group; IV, blank control group without any treatment. Uncomfortable symptoms, adverse events, and effectiveness rates were recorded on post-treatment day 14, 30, and 45.
On post-treatment day 14, the effectiveness rate in OFI-ALA-PDT group was obviously higher than that of the other three groups (P<0.05). However, no improved effects were observed in OFI-ALA-PDT group on day 30 and 45. During the period of treatment, the frequencies of uncomfortable symptoms in ALA-PDT group were obviously higher than those in the other three groups (P<0.05). The adverse event rate in OFI-ALA-PDT group was obviously lower than that of the ALA-PDT group (P<0.05).
The unblindness of the study and temporary animal models of acne induced may hamper the assessment and monitoring of the results, and future studies are still needed to clarify it further.
The OFI-ALA-PDT group (intra-tissue irradiation) showed no improved efficacy on treating rabbit ear acne but had higher safety and better tolerability.
外用氨基乙酰丙酸光动力疗法（ALA-PDT）已被证明对寻常痤疮有效。然而，治疗期间及治疗后会出现不良事件。
比较组织内光纤照射（OFI）ALA-PDT与传统ALA-PDT治疗兔寻常痤疮模型的疗效和耐受性。
选用25只清洁级家兔。随机选取20只家兔建立痤疮模型，另外5只作为对照。模型组家兔（40只耳朵）进一步分为四组（每组10只耳朵）：I组，将光纤头插入靶病变组织内进行OFI-ALA-PDT治疗；II组，传统ALA-PDT组；III组，OFI组；IV组，未进行任何治疗的空白对照组。在治疗后第14天、30天和45天记录不适症状、不良事件和有效率。
治疗后第14天，OFI-ALA-PDT组的有效率明显高于其他三组（P<0.05）。然而，在第30天和45天，OFI-ALA-PDT组未观察到改善效果。治疗期间，ALA-PDT组的不适症状发生频率明显高于其他三组（P<0.05）。OFI-ALA-PDT组的不良事件发生率明显低于ALA-PDT组（P<0.05）。
本研究未设盲以及所诱导的痤疮动物模型为临时性的，可能会影响结果的评估和监测，仍需进一步研究加以明确。
OFI-ALA-PDT组（组织内照射）在治疗兔耳痤疮方面未显示出更好的疗效，但具有更高的安全性和更好的耐受性。
