Aykut-Yetkiner Arzu, Attin Thomas, Wiegand Annette
Department of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Switzerland; Department of Pedodontics, Faculty of Dentistry, University of Ege, Izmir, Turkey.
Department of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Switzerland.
J Dent. 2014 Jul;42(7):856-61. doi: 10.1016/j.jdent.2014.03.011. Epub 2014 Apr 2.
This in vitro study aimed to investigate the preventive effect of brushing with anti-erosive toothpastes compared to a conventional fluoride toothpaste on dentine erosion.
Bovine dentine specimens (n=12 per subgroup) were eroded in an artificial mouth (6 days, 6×30 s/day) using either citric acid (pH:2.5) or a hydrochloric acid/pepsin solution (pH:1.6), simulating extrinsic or intrinsic erosive conditions, respectively. In between, the specimens were rinsed with artificial saliva. Twice daily, the specimens were brushed for 15 s in an automatic brushing machine at 2.5 N with a conventional fluoride toothpaste slurry (elmex, AmF) or toothpaste slurries with anti-erosive formulations: Apacare (NaF/1% nHAP), Biorepair (ZnCO3-HAP), Chitodent (Chitosan), elmex Erosionsschutz (NaF/AmF/SnCl2/Chitosan), mirasensitive hap (NaF/30% HAP), Sensodyne Proschmelz (NaF/KNO3). Unbrushed specimens served as control. Dentine loss was measured profilometrically and statistically analysed using two-way and one-way ANOVA followed by Scheffe's post hoc tests. RDA-values of all toothpastes were determined, and linear mixed models were applied to analyse the influence of toothpaste abrasivity on dentine wear (p<0.05).
Dentine erosion of unbrushed specimens amounted to 5.1±1.0 μm (extrinsic conditions) and 12.9±1.4 μm (intrinsic conditions). All toothpastes significantly reduced dentine erosion by 24-67% (extrinsic conditions) and 21-40% (intrinsic conditions). Biorepair was least effective, while all other toothpastes were not significantly different from each other. Linear mixed models did not show a significant effect of the RDA-value of the respective toothpaste on dentine loss.
Toothpastes with anti-erosive formulations reduced dentine erosion, especially under simulated extrinsic erosive conditions, but were not superior to a conventional fluoride toothpaste.
本体外研究旨在调查与传统含氟牙膏相比，使用抗侵蚀牙膏刷牙对牙本质侵蚀的预防作用。
牛牙本质标本（每个亚组12个）在人工口腔中分别用柠檬酸（pH值：2.5）或盐酸/胃蛋白酶溶液（pH值：1.6）进行侵蚀（6天，每天6次，每次30秒），分别模拟外源性或内源性侵蚀情况。其间，标本用人工唾液冲洗。每天两次，将标本在自动刷牙机中以2.5 N的力用传统含氟牙膏糊剂（elmex，含胺甲环酸）或含抗侵蚀配方的牙膏糊剂刷牙15秒：Apacare（氟化钠/1%纳米羟基磷灰石）、Biorepair（碱式碳酸锌 - 羟基磷灰石）、Chitodent（壳聚糖）、elmex Erosionsschutz（氟化钠/胺甲环酸/氯化亚锡/壳聚糖）、mirasensitive hap（氟化钠/30%羟基磷灰石）、舒适达专业修复（氟化钠/硝酸钾）。未刷牙的标本作为对照。使用轮廓仪测量牙本质损失，并采用双向和单向方差分析以及Scheffe事后检验进行统计分析。测定所有牙膏的磨损率数值，并应用线性混合模型分析牙膏磨蚀性对牙本质磨损的影响（p<0.05）。
未刷牙标本的牙本质侵蚀在（外源性情况）下为5.1±1.0μm，在（内源性情况）下为12.9±1.4μm。所有牙膏均显著减少牙本质侵蚀，在外源性情况下减少24 - 67%，在内源性情况下减少21 - 40%。Biorepair效果最差，而其他所有牙膏之间无显著差异。线性混合模型未显示各牙膏的磨损率数值对牙本质损失有显著影响。
含抗侵蚀配方的牙膏可减少牙本质侵蚀，尤其是在模拟外源性侵蚀情况下，但并不优于传统含氟牙膏。
