Department of Preventive Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Sci Rep. 2023 Jul 5;13(1):10884. doi: 10.1038/s41598-023-38043-7.
This in vitro study aimed to analyse the effect of various children's toothpastes on erosive tooth wear of primary bovine enamel and dentin. Enamel and dentin specimens (n = 12) were cyclically eroded (6 × 60 s/d, citric acid, pH 2.4) and brushed (2 × 15 s/d, 2 N) over 5 days. Nine fluoride toothpastes (500 to 1450 ppm) and eight toothpastes containing no fluoride or other active ingredients (hydroxyapatite and/or xylitol) were tested. Unbrushed specimens served as control. Tissue loss was quantified using widefield confocal microscopy and statistically analysed using two-way and one-way ANOVAs followed by Scheffe's (enamel) or Tamhane's (dentin) post-hoc tests (p < 0.05). Only one fluoride toothpaste (1400 ppm) was able to reduce erosive wear of enamel significantly by 15% compared to the control (p = 0.002). All fluoridated toothpastes reduced dentin surface loss significantly by 32 to 69% compared to the control (p ≤ 0.001), while fluoride-free toothpastes were unable to reduce dentin loss significantly (p ≥ 0.971). Most fluoridated toothpastes caused less erosive wear compared to fluoride-free toothpastes. Children toothpastes containing fluoride were more effective in reducing erosive wear compared to toothpastes containing no fluoride or other active ingredients.
本体外研究旨在分析各种儿童牙膏对牛牙釉质和牙本质腐蚀性磨损的影响。釉质和牙本质标本（n=12）在 5 天内经历了周期性的侵蚀（6×60 s/d，柠檬酸，pH 值 2.4）和刷洗（2×15 s/d，2 N）。测试了 9 种含氟牙膏（500 至 1450 ppm）和 8 种不含氟或其他活性成分（羟磷灰石和/或木糖醇）的牙膏。未刷洗的标本作为对照。使用宽场共聚焦显微镜定量组织损失，并使用双向和单向 ANOVA 进行统计分析，然后使用 Scheffe（牙釉质）或 Tamhane（牙本质）事后检验（p<0.05）。只有一种含氟牙膏（1400 ppm）与对照相比，能显著减少牙釉质腐蚀性磨损 15%（p=0.002）。所有含氟牙膏与对照相比，能显著减少牙本质表面损失 32%至 69%（p≤0.001），而不含氟的牙膏则不能显著减少牙本质损失（p≥0.971）。与不含氟的牙膏相比，大多数含氟牙膏引起的腐蚀性磨损更少。与不含氟或其他活性成分的牙膏相比，含氟的儿童牙膏在减少腐蚀性磨损方面更有效。
