营养诱导的肠道适应性及其在肥胖中的作用。
Nutrient-induced intestinal adaption and its effect in obesity.
作者信息
Dailey Megan J
机构信息
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
Physiol Behav. 2014 Sep;136:74-8. doi: 10.1016/j.physbeh.2014.03.026. Epub 2014 Apr 1.
Abstract
Obese and lean individuals respond differently to nutrients with changes in digestion, absorption and hormone release. This may be a result of differences in intestinal epithelial morphology and function driven by the hyperphagia or the type of diet associated with obesity. It is well known that the maintenance and growth of the intestine is driven by the amount of luminal nutrients, with high nutrient content resulting in increases in cell number, villi length and crypt depth. In addition, the type of nutrient appears to contribute to alterations in the morphology and function of the epithelial cells. This intestinal adaptation may be what is driving the differences in nutrient processing in lean versus obese individuals. This review describes how nutrients may be able to induce changes in intestinal epithelial cell proliferation, differentiation and function and the link between intestinal adaptation and obesity.
摘要
肥胖个体和瘦个体对营养物质的反应不同，在消化、吸收和激素释放方面存在变化。这可能是由肥胖相关的多食或饮食类型所驱动的肠道上皮形态和功能差异导致的。众所周知，肠道的维持和生长由肠腔内营养物质的量驱动，高营养含量会导致细胞数量增加、绒毛长度增加和隐窝深度增加。此外，营养物质的类型似乎会导致上皮细胞形态和功能的改变。这种肠道适应性可能是导致瘦个体与肥胖个体在营养处理上存在差异的原因。这篇综述描述了营养物质如何能够诱导肠道上皮细胞增殖、分化和功能的变化，以及肠道适应性与肥胖之间的联系。
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