Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/CSIC/JA, Carretera de Utrera km 1, 41013 Sevilla, Spain.
Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/CSIC/JA, Carretera de Utrera km 1, 41013 Sevilla, Spain.
Semin Cell Dev Biol. 2014 Apr;28:104-9. doi: 10.1016/j.semcdb.2014.03.031. Epub 2014 Apr 3.
Considering the degree of detail available at the genetic and cellular levels, the Drosophila ovary stands out as a powerful system to identify new players in the regulation of key aspects of cancer progression. In this review, we will comment on how the use of the Drosophila ovary has helped to elucidate some of the molecular bases of ovarian malignancies and to identify and characterize critical tumour suppressor genes and oncogenes with an impact in human pathologies.
考虑到在基因和细胞水平上的详细程度，果蝇卵巢是一个强大的系统，可以用来鉴定在癌症进展的关键方面的调控中的新参与者。在这篇综述中，我们将评论使用果蝇卵巢如何帮助阐明一些卵巢恶性肿瘤的分子基础，并鉴定和描述具有人类病理学影响的关键肿瘤抑制基因和癌基因。
