从红树林植物老鼠簕内生真菌黄曲霉 AIL8 中得到的新苯衍生物。

New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius.

机构信息

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Guangdong Institute of Microbiology, Guangzhou 510070, China.

出版信息

Fitoterapia. 2014 Jun;95:194-202. doi: 10.1016/j.fitote.2014.03.021. Epub 2014 Apr 2.

DOI:10.1016/j.fitote.2014.03.021

PMID:24704337

Abstract

Two new aromatic butyrolactones, flavipesins A (1) and B (2), two new natural products (3 and 4), and a known phenyl dioxolanone (5) were isolated from marine-derived endophytic fungus Aspergillus flavipes. The structures of compounds 1-5 were elucidated by 1D- and 2D-NMR and MS analysis, the absolute configurations were assigned by optical rotation and CD data, and the stereochemistry of 1 was determined by X-ray crystallography analysis. 1 demonstrated lower MIC values against Staphylococcus aureus (8.0 μg/mL) and Bacillus subtillis (0.25 μg/mL). 1 also showed the unique antibiofilm activity of penetration through the biofilm matrix and kills live bacteria inside mature S. aureus biofilm.

摘要

从海洋来源的内生真菌黄曲霉中分离得到两种新的芳香丁内酯， flavipesins A (1) 和 B (2)，两种新的天然产物 (3 和 4) 和一种已知的苯并二氧杂环戊酮 (5)。通过 1D- 和 2D-NMR 和 MS 分析阐明了化合物 1-5 的结构，通过旋光和 CD 数据确定了绝对构型，并通过 X 射线晶体学分析确定了 1 的立体化学。1 对金黄色葡萄球菌（8.0 μg/mL）和枯草芽孢杆菌（0.25 μg/mL）的 MIC 值较低。1 还表现出独特的抗生物膜活性，可穿透生物膜基质并杀死成熟金黄色葡萄球菌生物膜内的活细菌。