National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China.
Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Curr Opin Virol. 2014 Apr;5:91-7. doi: 10.1016/j.coviro.2014.03.001. Epub 2014 Apr 3.
Human infections by the newly reassorted avian influenza A (H7N9) virus were reported for the first time in early 2013, and the virus was confirmed to be a low pathogenic avian influenza virus in poultry. Because continuously reported cases have been increasing since the summer of 2013, this novel virus poses a potential threat to public health in China and is attracting broad attention worldwide. In this review, we summarize and discuss the characteristics of the H7N9 virus revealed by the recent timely studies from the perspectives of epidemiology, host preference, clinical manifestations, immunopathogenesis, drug resistance, vaccine development, and burden of disease. This knowledge about the novel avian-origin H7N9 virus will provide a useful reference for clinical interventions of human infections and help to rapidly pave the way to develop an efficient and safe vaccine.
人感染新型禽流感病毒 A（H7N9）于 2013 年初首次报告，该病毒被证实为家禽中的低致病性禽流感病毒。由于自 2013 年夏季以来持续报告的病例不断增加，这种新型病毒对中国的公共卫生构成潜在威胁，引起了全球的广泛关注。在这篇综述中，我们从流行病学、宿主偏好、临床表现、免疫发病机制、耐药性、疫苗开发和疾病负担等方面总结和讨论了近期及时研究揭示的 H7N9 病毒的特征。这些关于新型禽流感 H7N9 病毒的知识将为人类感染的临床干预提供有用的参考，并有助于快速为开发有效和安全的疫苗铺平道路。
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