Pan Chen-Wei, Lin Yi
*MD, PhD †MSc School of Public Health, Medical College of Soochow University, Suzhou, China (C-WP); Singapore Eye Research Institute, Singapore (C-WP); and Unit of Nutrition and Food Safety, Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Belgium (YL).
Optom Vis Sci. 2014 May;91(5):478-83. doi: 10.1097/OPX.0000000000000243.
To examine the longitudinal association of overweight/obesity with age-related cataract.
A systematic review of the literature was performed using PubMed and Embase from their inception until June 2013 for prospective data on body mass index categories identical or similar to the World Health Organization-recommended classifications of body weight and age-related cataract including nuclear, cortical, and posterior subcapsular (PSC) cataract. Meta-analyses were conducted using random-effects models with results reported as adjusted relative risks (RRs).
A total of 163,013 subjects aged 40 to 84 years from six prospective cohort studies were included in the meta-analysis. Obesity was associated with an increasing risk of nuclear cataract (pooled RR, 1.12; 95% confidence interval [CI], 1.02 to 1.25), cortical cataract (pooled RR, 1.34; 95% CI, 1.07 to 1.66), and PSC cataract (pooled RR, 1.52; 95% CI, 1.31 to 1.77). Overweight was only associated with an increasing risk of PSC cataract (pooled RR, 1.23; 95% CI, 1.09 to 1.40).
The longitudinal associations of obesity with incident age-related cataract are confirmed by the findings in this six-study meta-analysis. The association of obesity with PSC cataract is stronger than that with nuclear or cortical cataract. Randomized control trials are warranted to examine the effectiveness and cost-effectiveness of weight reduction in obese populations to decrease the risk of age-related cataract.
探讨超重/肥胖与年龄相关性白内障的纵向关联。
利用PubMed和Embase数据库，对从数据库建立至2013年6月期间的文献进行系统回顾，以获取与世界卫生组织推荐的体重分类相同或相似的体重指数类别以及年龄相关性白内障（包括核性、皮质性和后囊下白内障）的前瞻性数据。采用随机效应模型进行荟萃分析，结果以调整后的相对风险（RRs）表示。
六项前瞻性队列研究中共有163,013名年龄在40至84岁之间的受试者纳入荟萃分析。肥胖与核性白内障风险增加相关（合并RR，1.12；95%置信区间[CI]，1.02至1.25）、皮质性白内障（合并RR，1.34；95%CI，1.07至1.66）和后囊下白内障（合并RR，1.52；95%CI，1.31至1.77）。超重仅与后囊下白内障风险增加相关（合并RR，1.23；95%CI，1.09至1.40）。
这项六项研究的荟萃分析结果证实了肥胖与年龄相关性白内障发病之间的纵向关联。肥胖与后囊下白内障的关联强于与核性或皮质性白内障的关联。有必要进行随机对照试验，以检验肥胖人群减轻体重降低年龄相关性白内障风险的有效性和成本效益。
