Niazi Sana, Moshirfar Majid, Dastjerdi Mohammad H, Niazi Feizollah, Doroodgar Farideh, Ambrósio Renato
Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran, Iran.
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Nutr. 2024 Jan 31;10:1215212. doi: 10.3389/fnut.2023.1215212. eCollection 2023.
There are inconsistent findings on the association between obesity and age-related cataract (ARC). This systematic review was done to summarize available findings on the association between obesity [defined by body mass index (BMI)] and ARC by performing a dose-response meta-analysis on eligible prospective cohort studies.
We performed a systematic search in PubMed, Scopus, ISI Web of Knowledge, and Google Scholar until June 2022 to identify eligible publications.
In total, 16 studies with a total sample size of 1,607,125 participants were included. Among all of these studies, there were 103,897 cases of ARC. In the follow-up periods ranging between 4 and 28 years, 4,870 cases of nuclear cataract, 1,611 cases of cortical cataract, and 1,603 cases of posterior subcapsular cataracts (PSC) were detected. By comparing the highest and lowest categories of BMI, we found that higher BMI was associated with an increased risk of ARC (RR: 1.18, 95% CI: 1.09-1.28) and PSC (RR: 1.44, 95% CI: 1.08-1.90). In the dose-response analysis, each 5 kg/m increase in BMI was associated with a 6 and 27% increased risk of ARC (RR: 1.06, 95% CI: 1.01-1.12) and PSC (RR: 1.27, 95% CI: 1.14-1.41), respectively. In addition, we found a positive association for cortical cataract among high-quality studies, in which higher BMI was associated with a 20% increased risk of cortical cataract (RR: 1.20, 95% CI: 1.02-1.42). In terms of nuclear cataract, we found no significant association either in the comparison between the highest and lowest categories of BMI or in the dose-response meta-analysis.
Obesity (defined by BMI) was associated with an increased risk of ARC, PSC, and cortical cataract in adults. However, such a positive association was not seen for nuclear cataract.
CRD42022357132.
关于肥胖与年龄相关性白内障（ARC）之间的关联，研究结果并不一致。本系统评价旨在通过对符合条件的前瞻性队列研究进行剂量反应荟萃分析，总结肥胖（以体重指数（BMI）定义）与ARC之间关联的现有研究结果。
我们在PubMed、Scopus、ISI Web of Knowledge和谷歌学术中进行了系统检索，直至2022年6月，以确定符合条件的出版物。
总共纳入了16项研究，样本总量为1,607,125名参与者。在所有这些研究中，有103,897例ARC病例。在4至28年的随访期内，检测到4,870例核性白内障、1,611例皮质性白内障和1,603例后囊下白内障（PSC）。通过比较BMI的最高和最低类别，我们发现较高的BMI与ARC风险增加（RR：1.18，95%CI：1.09 - 1.28）和PSC风险增加（RR：1.44，95%CI：1.08 - 1.90）相关。在剂量反应分析中，BMI每增加5kg/m²，ARC（RR：1.06，95%CI：1.01 - 1.12）和PSC（RR：1.27，95%CI：1.14 - 1.41）的风险分别增加6%和27%。此外，我们在高质量研究中发现皮质性白内障存在正相关，其中较高的BMI与皮质性白内障风险增加20%相关（RR：1.20，95%CI：1.02 - 1.42）。就核性白内障而言，在BMI最高和最低类别之间的比较以及剂量反应荟萃分析中均未发现显著关联。
肥胖（以BMI定义）与成年人ARC、PSC和皮质性白内障风险增加相关。然而，核性白内障未观察到这种正相关。
PROSPERO注册编号：CRD42022357132。
