Faculty of Medicine, Technion - Israel Institute of Technology, 1 Efron St., Haifa 31096, Israel.
Department of Neurobiology, Weizmann Institute of Science, Herzl St., Rehovot 76100, Israel.
Curr Opin Neurobiol. 2014 Apr;25:20-4. doi: 10.1016/j.conb.2013.10.008. Epub 2013 Dec 4.
Working memory is a system that maintains and manipulates information for several seconds during the planning and execution of many cognitive tasks. Traditionally, it was believed that the neuronal underpinning of working memory is stationary persistent firing of selective neuronal populations. Recent advances introduced new ideas regarding possible mechanisms of working memory, such as short-term synaptic facilitation, precise tuning of recurrent excitation and inhibition, and intrinsic network dynamics. These ideas are motivated by computational considerations and careful analysis of experimental data. Taken together, they may indicate the plethora of different processes underlying working memory in the brain.
工作记忆是一个系统,在许多认知任务的规划和执行过程中,可以维持和操作信息几秒钟。传统上,人们认为工作记忆的神经元基础是选择性神经元群体的固定持续放电。最近的进展提出了关于工作记忆可能机制的新想法,例如短期突触易化、递归兴奋和抑制的精确调谐以及内在网络动力学。这些想法是基于计算考虑和对实验数据的仔细分析提出的。总的来说,它们可能表明大脑中工作记忆的基础是大量不同的过程。