Wyss Institute for Biologically Inspired Engineering Harvard University, Boston, MA, USA Department of Biomedical Engineering, Boston University, Boston, MA, USA.
EMBO J. 2014 May 16;33(10):1089-90. doi: 10.1002/embj.201488452. Epub 2014 Apr 7.
Endothelial sprouting during angiogenesis is a highly coordinated morphogenetic process that involves polarized tip cells leading stalk cells to form new capillaries. While tip and stalk cells previously were thought to be stable and have static phenotypes within the sprout, it is becoming increasingly clear that endothelial cells undergo dynamic rearrangements. A new study using computer simulations, validated by in vitro and in vivo experimental data, now provides an explanation for these rearrangements, showing that sprouting cells are in a continuum of migratory states, regulated by differential cell-cell adhesions and protrusive activities to drive proper vascular organization.
血管生成过程中的血管内皮细胞发芽是一个高度协调的形态发生过程，涉及极化的尖端细胞引导衬里细胞形成新的毛细血管。虽然以前认为尖端和衬里细胞在芽中是稳定的，并且具有静态表型，但越来越明显的是，内皮细胞会发生动态重排。一项新的研究使用计算机模拟，并通过体外和体内实验数据进行验证，现在为这些重排提供了一个解释，表明发芽细胞处于迁移状态的连续体中，受细胞-细胞黏附差异和突起活动的调节，以驱动血管的正确组织。
