Peng Qing-Lin, Shu Xiao-Ming, Wang Dong-Xue, Wang Yan, Lu Xin, Wang Guo-Chun
Department of Rheumatology, China-Japan Friendship Hospital, Ying Hua East Road, Chao Yang District, Beijing 100029, China.
Biomark Med. 2014;8(3):395-403. doi: 10.2217/bmm.13.124.
To investigate serum levels of B-cell activating factor (BAFF) in the patients with polymyositis (PM) and dermatomyositis (DM), and to systematically examine the association between serum BAFF levels and disease activity in PM/DM patients.
PATIENTS & METHODS: A cross-sectional analysis included 92 PM/DM patients and 25 healthy control subjects. A longitudinal study followed 24 patients. Serum BAFF concentrations were detected by the ELISA method.
Serum BAFF levels in PM/DM patients were significantly higher than those in healthy controls. A cross-sectional assessment revealed a modest correlation between serum BAFF levels and global disease activity and a mild correlation between serum BAFF levels and muscle disease activity. The longitudinal study showed that serum BAFF levels modestly correlated with global disease activity and muscle disease activity.
Resulting data showed high serum BAFF levels in PM/DM patients and suggested BAFF as a serological biomarker for PM/DM disease activity.
研究多发性肌炎（PM）和皮肌炎（DM）患者血清B细胞活化因子（BAFF）水平，并系统检测血清BAFF水平与PM/DM患者疾病活动度之间的关联。
一项横断面分析纳入了92例PM/DM患者和25例健康对照者。一项纵向研究跟踪了24例患者。采用酶联免疫吸附测定（ELISA）法检测血清BAFF浓度。
PM/DM患者的血清BAFF水平显著高于健康对照者。横断面评估显示血清BAFF水平与整体疾病活动度之间存在适度相关性，与肌肉疾病活动度之间存在轻度相关性。纵向研究表明血清BAFF水平与整体疾病活动度和肌肉疾病活动度存在适度相关性。
所得数据显示PM/DM患者血清BAFF水平较高，并提示BAFF可作为PM/DM疾病活动度的血清学生物标志物。
