Guthrie S C, Gilula N B
Trends Neurosci. 1989 Jan;12(1):12-6. doi: 10.1016/0166-2236(89)90150-1.
Embryonic development requires extensive interaction between cells; cell-to-cell communication through gap junctions may be one mechanism involved. Much correlative evidence suggests gap junctions are involved in cellular interactions during development. Recently, the biological role of junctions has been investigated using antibodies prepared against the major rat liver gap junction protein. Disrupting normal patterns of intercellular communication with such antibodies can drastically perturb development. Recent experiments emphasize, in particular, the importance of gap junctional communication for patterning processes.
胚胎发育需要细胞之间广泛的相互作用；通过间隙连接进行的细胞间通讯可能是其中一种机制。许多相关证据表明，间隙连接参与发育过程中的细胞相互作用。最近，利用针对大鼠肝脏主要间隙连接蛋白制备的抗体对连接的生物学作用进行了研究。用此类抗体破坏细胞间通讯的正常模式会严重扰乱发育。最近的实验尤其强调了间隙连接通讯对模式形成过程的重要性。
