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通过身体肥胖指数和多变量心血管疾病风险评估的肥胖症

Obesity as assessed by body adiposity index and multivariable cardiovascular disease risk.

作者信息

Dhaliwal Satvinder S, Welborn Timothy A, Goh Louise G H, Howat Peter A

机构信息

Curtin University, Perth, Australia.

Sir Charles Gairdner Hospital, Perth, Australia.

出版信息

PLoS One. 2014 Apr 8;9(4):e94560. doi: 10.1371/journal.pone.0094560. eCollection 2014.

Abstract

To assess the role of body adiposity index (BAI) in predicting cardiovascular disease (CVD) and coronary heart disease (CHD) mortality, in comparison with body mass index (BMI), waist circumference (WC), and the waist circumference to hip circumference ratio (WHR). This study was a prospective 15 year mortality follow-up of 4175 Australian males, free of heart disease, diabetes and stroke. The Framingham Risk Scores (FRS) for CHD and CVD death were calculated at baseline for all subjects. Multivariable logistic regression was used to assess the effects of the measures of obesity on CVD and CHD mortality, before adjustment and after adjustment for FRS. The predictive ability of BAI, though present in the unadjusted analyses, was generally not significant after adjustment for age and FRS for both CVD and CHD mortality. BMI behaved similarly to BAI in that its predictive ability was generally not significant after adjustments. Both WC and WHR were significant predictors of CVD and CHD mortality and remained significant after adjustment for covariates. BAI appeared to be of potential interest as a measure of % body fat and of obesity, but was ineffective in predicting CVD and CHD.

摘要

为评估身体肥胖指数(BAI)在预测心血管疾病(CVD)和冠心病(CHD)死亡率方面的作用,并与体重指数(BMI)、腰围(WC)以及腰臀比(WHR)进行比较。本研究对4175名无心脏病、糖尿病和中风的澳大利亚男性进行了为期15年的前瞻性死亡率随访。在基线时为所有受试者计算冠心病和心血管疾病死亡的弗雷明汉风险评分(FRS)。多变量逻辑回归用于评估肥胖指标在调整FRS之前和之后对心血管疾病和冠心病死亡率的影响。BAI的预测能力虽然在未调整分析中存在,但在对心血管疾病和冠心病死亡率进行年龄和FRS调整后通常不显著。BMI的表现与BAI相似,即其预测能力在调整后通常不显著。WC和WHR都是心血管疾病和冠心病死亡率的显著预测指标,在对协变量进行调整后仍然显著。BAI作为身体脂肪百分比和肥胖的一种测量方法似乎具有潜在意义,但在预测心血管疾病和冠心病方面无效。

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