Tanriover Mine Durusu, Guncu Guliz N, Oz S Gul, Ercan Esra, Karabulut Erdem, Nazliel-Erverdi Haviye
Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey,
Rheumatol Int. 2014 Nov;34(11):1563-9. doi: 10.1007/s00296-014-3004-4. Epub 2014 Apr 9.
Most patients with osteoporosis are postmenopausal women or senile people who are deemed to have primary osteoporosis. However, young women, males, and atypical cases need further work up to evaluate the risk factors for secondary osteoporosis. A growing body of literature has accumulated regarding the role of osteoporosis in the onset and progression of periodontal disease and tooth loss. We hypothesized that secondary/idiopathic osteoporosis in young patients will be associated with worse periodontal status. Patients and controls who were seen in the general internal medicine outpatient clinic and who were less than 47 years of age were recruited between December 2005 and June 2011. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Blood samples were obtained for bone turnover markers and secondary causes of low BMD. Periodontal variables were assessed. Forty-five women whose mean age was 33.9 ± 7.7 years were enrolled. The osteoporotic group consisted of 12 patients, the osteopenic group 17 patients, and the control group 16 subjects. Significantly higher gingival recession (GR), gingival bleeding time index, and hence gingival inflammation were noted in patients with secondary osteoporosis compared to healthy subjects. In logistic regression analysis, having osteoporosis was determined as the single risk factor for increased bleeding time (b = 0.871, p = 0.008), while having osteoporosis (b = 0.181, p = 0.001) and age (b = 0.010, p < 0.001) were significant parameters with regard to GR. In conclusion, low BMD in young individuals was associated with greater gingival inflammation and recession when compared to those individuals with normal BMD values.
大多数骨质疏松症患者是绝经后女性或老年人，被认为患有原发性骨质疏松症。然而，年轻女性、男性以及非典型病例需要进一步检查以评估继发性骨质疏松症的风险因素。关于骨质疏松症在牙周疾病的发生和发展以及牙齿脱落中的作用，已有越来越多的文献积累。我们假设年轻患者的继发性/特发性骨质疏松症将与更差的牙周状况相关。2005年12月至2011年6月期间，招募了在普通内科门诊就诊且年龄小于47岁的患者和对照。通过双能X线吸收法测量骨密度（BMD）。采集血样检测骨转换标志物和低骨密度的继发性原因。评估牙周变量。纳入了45名平均年龄为33.9±7.7岁的女性。骨质疏松组有12名患者，骨量减少组有17名患者，对照组有16名受试者。与健康受试者相比，继发性骨质疏松症患者的牙龈退缩（GR）、牙龈出血时间指数显著更高，因此牙龈炎症更明显。在逻辑回归分析中，骨质疏松被确定为出血时间增加的单一风险因素（b = 0.871，p = 0.008），而骨质疏松（b = 0.181，p = 0.001）和年龄（b = 0.010，p < 0.001）是与GR相关的显著参数。总之，与骨密度正常的个体相比，年轻个体的低骨密度与更严重的牙龈炎症和退缩相关。
