Department of Health, Feira de Santana State University, Feira de Santana, Bahia, Brazil,
Osteoporos Int. 2013 Apr;24(4):1275-83. doi: 10.1007/s00198-012-2130-7. Epub 2012 Sep 22.
This study investigated whether osteoporosis/osteopenia has an influence on the progression of periodontitis in postmenopausal women. The findings highlight that postmenopausal women with osteoporosis/osteopenia had a greater chance of presenting periodontitis than those with normal bone mineral density, particularly among nonusers of osteoporosis medications and women with a greater number of remaining teeth, showing that osteoporosis/osteopenia has had an influence on the progression of periodontitis.
This study investigated whether osteoporosis/osteopenia has an influence on the progression of periodontitis in postmenopausal women and explored the effects of use of osteoporosis medication and tooth loss on this association.
This case-control study involved 521 postmenopausal women, with minimum age of 50 years, in Feira de Santana, Bahia, Brazil. Sociodemographic characteristics, health conditions/medications, and lifestyle habits were recorded. A complete periodontal examination was performed and periodontitis was diagnosed. Bone mineral density was evaluated through lumbar spine and femoral bone densitometry, obtained using dual-energy X-ray absorptiometry. Logistic regression was used to calculate the strength of association between the occurrences of osteoporosis/osteopenia and periodontitis.
Women with osteoporosis/osteopenia were twice as likely to present periodontitis, as were those with normal bone mineral density, even after adjusting for smoking, age, family income, and last visit to dentist (odds ratios (OR)adjusted=2.24, 95% CI [1.24-4.06], p=0.008). Among nonusers of osteoporosis medication (ORadjusted=2.51, 95% CI [1.33-4.73], p=0.004) and women with at least 10 remaining teeth (ORadjusted=2.50 95% CI [1.18-5.27], p=0.02), the odds ratio was higher and statistically significant.
These findings highlight that postmenopausal women with osteoporosis/osteopenia had a greater chance of presenting periodontitis than those with normal bone mineral density, particularly among nonusers of osteoporosis medications and women with a greater number of remaining teeth.
本研究旨在探讨绝经后妇女骨质疏松/骨量减少是否会影响牙周炎的进展，并探讨骨质疏松症药物使用和牙齿缺失对这种相关性的影响。
本病例对照研究纳入了巴西巴伊亚州费拉迪圣安娜的 521 名绝经后妇女，最小年龄 50 岁。记录了社会人口统计学特征、健康状况/用药和生活方式习惯。进行了全面的牙周检查，并诊断了牙周炎。通过腰椎和股骨骨密度双能 X 射线吸收法评估骨矿物质密度。使用逻辑回归计算骨质疏松/骨量减少与牙周炎发生之间的关联强度。
患有骨质疏松/骨量减少的妇女发生牙周炎的可能性是骨密度正常妇女的两倍，即使在校正了吸烟、年龄、家庭收入和最近一次看牙医的时间后（调整后的优势比[ORadjusted]=2.24，95%可信区间[CI] [1.24-4.06]，p=0.008）。在未使用骨质疏松症药物的妇女（调整后的 ORadjusted=2.51，95%CI [1.33-4.73]，p=0.004）和至少有 10 颗剩余牙齿的妇女（调整后的 ORadjusted=2.50，95%CI [1.18-5.27]，p=0.02）中，比值比更高且具有统计学意义。
这些发现强调了骨质疏松/骨量减少的绝经后妇女发生牙周炎的可能性大于骨密度正常的妇女，尤其是在未使用骨质疏松症药物和剩余牙齿较多的妇女中。
