印度北部MC4R基因[rs17782313、rs17700633]、AGRP基因[rs3412352]和POMC基因[rs1042571]多态性与肥胖的相关性评估
Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India.
作者信息
Srivastava Apurva, Mittal Balraj, Prakash Jai, Narain Varun Shanker, Natu S M, Srivastava Neena
机构信息
Department of Physiology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, Uttar Pradesh, India 226014.
出版信息
Oman Med J. 2014 Mar;29(2):114-8. doi: 10.5001/omj.2014.28.
OBJECTIVE
Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity. Therefore, the aim of this study is to examine MC4R rs17782313, MC4R rs17700633, AGRP rs3412352 and POMCrs1042571 for any association with obesity in North Indian subjects.
METHODS
The variants were investigated for association in 300 individuals with BMI ≥30 kg/m(2) and 300 healthy non-obese individuals BMI <30 kg/m(2.) The genotyping were analyzed by Taqman probes. The statistical analysis was performed by the SPSS software, ver.19 and p≤0.05 was considered statistically significant.
RESULTS
The genotypes of MC4R rs17782313 and POMC rs1042571 were significantly associated with obesity (C), (p=0.02; OR=1.7 and p=0.01; OR=1.6, respectively); however, MC4Rrs17700633 (p=0.001; OR=0.55) was associated with low risk. In addition, AGRPrs3412352 (p=0.93; OR=0.96) showed no association with obesity (BMI ≥30 kg/m(2)) in North Indian subjects.
CONCLUSION
This study provides the report about the significant association of MC4R (rs17782313) and POMC (rs1042571) with morbid obesity (BMI ≥30 kg/m(2)), but MC4R (rs17700633) and AGRP (rs34123523) did not show any association with obesity in the studied North Indian population.
目的
据报道，黑皮质素-4受体基因（MC4R）、刺鼠相关蛋白（AGRP）和阿片促黑皮质素原（POMC）的基因变异与肥胖有关。因此，本研究旨在检测MC4R rs17782313、MC4R rs17700633、AGRP rs3412352和POMC rs1042571与北印度人群肥胖的相关性。
方法
对300名体重指数（BMI）≥30 kg/m²的个体和300名BMI<30 kg/m²的健康非肥胖个体进行基因变异相关性研究。采用Taqman探针进行基因分型分析。使用SPSS软件19版进行统计分析，p≤0.05被认为具有统计学意义。
结果
MC4R rs17782313和POMC rs1042571的基因型与肥胖显著相关（C，p=0.02；比值比[OR]=1.7；p=0.01；OR=1.6）；然而，MC4R rs17700633（p=0.001；OR=0.55）与低风险相关。此外，AGRP rs3412352（p=0.93；OR=0.96）在北印度人群中与肥胖（BMI≥30 kg/m²）无相关性。
结论
本研究报告了MC4R（rs17782313）和POMC（rs1042571）与病态肥胖（BMI≥30 kg/m²）的显著相关性，但在研究的北印度人群中，MC4R（rs17700633）和AGRP（rs34123523）与肥胖无相关性。
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