• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India.印度北部MC4R基因[rs17782313、rs17700633]、AGRP基因[rs3412352]和POMC基因[rs1042571]多态性与肥胖的相关性评估
Oman Med J. 2014 Mar;29(2):114-8. doi: 10.5001/omj.2014.28.
2
Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.对北印度人黑素皮质素4受体（MC4R）rs17782313、阿黑皮素原（POMC）rs1042571、载脂蛋白E-Hha1和刺鼠相关蛋白（AGRP）rs3412352基因变异与肥胖风险易感性的分析。
Ann Hum Biol. 2016 May;43(3):285-8. doi: 10.3109/03014460.2015.1061597. Epub 2015 Jul 31.
3
Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.MC4R附近的变异与肥胖相关，并影响中年人群中与肥胖相关的数量性状：对14940名丹麦人的研究。
Diabetes. 2009 Mar;58(3):757-64. doi: 10.2337/db08-0620. Epub 2008 Dec 10.
4
MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.MC4R 变异 rs12970134 和 rs17782313 与沙特阿拉伯西部地区肥胖型多囊卵巢综合征患者相关。
BMC Med Genet. 2019 Aug 20;20(1):144. doi: 10.1186/s12881-019-0876-x.
5
Melanocortin-4 receptor (MC4R) rs17782313 polymorphism interacts with Dietary Approach to Stop Hypertension (DASH) and Mediterranean Dietary Score (MDS) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals.黑皮质素-4受体（MC4R）rs17782313多态性与终止高血压饮食方法（DASH）及地中海饮食评分（MDS）相互作用，影响肥胖个体的下丘脑激素和心血管代谢危险因素。
Genes Nutr. 2020 Aug 5;15(1):13. doi: 10.1186/s12263-020-00672-2.
6
Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.MC4R 附近常见变异与体脂肪、体脂分布、代谢特征和能量消耗的关系。
Int J Obes (Lond). 2010 Jan;34(1):182-9. doi: 10.1038/ijo.2009.215. Epub 2009 Oct 20.
7
Analysis of the Impact of Common Polymorphisms of the FTO and MC4R Genes with the Risk of Severe Obesity in Saudi Arabian Population.沙特阿拉伯人群中FTO和MC4R基因常见多态性对重度肥胖风险的影响分析
Genet Test Mol Biomarkers. 2018 Mar;22(3):170-177. doi: 10.1089/gtmb.2017.0218. Epub 2018 Feb 21.
8
Association of MC4R (rs17782313) gene polymorphism with obesity measures in Western India.MC4R（rs17782313）基因多态性与印度西部肥胖指标的相关性研究。
Diabetes Metab Syndr. 2021 May-Jun;15(3):661-665. doi: 10.1016/j.dsx.2021.03.013. Epub 2021 Mar 19.
9
Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension.FTO基因的RS9939906位点和MC4R基因的RS17782313位点对高血压患者肥胖、2型糖尿病及血压的影响
Cardiovasc Diabetol. 2013 Jul 12;12:103. doi: 10.1186/1475-2840-12-103.
10
The Melanocortin System in Atlantic Salmon ( L.) and Its Role in Appetite Control.大西洋鲑（L.）中的黑皮质素系统及其在食欲控制中的作用。
Front Neuroanat. 2020 Aug 21;14:48. doi: 10.3389/fnana.2020.00048. eCollection 2020.

引用本文的文献

1
Understanding food addiction in obesity: a genetic perspective.从遗传学角度理解肥胖中的食物成瘾
J Eat Disord. 2025 Aug 28;13(1):191. doi: 10.1186/s40337-025-01387-8.
2
MC4R variant rs17782313 and manifestation of obese phenotype in Pakistani females.黑素皮质素4受体（MC4R）基因变体rs17782313与巴基斯坦女性肥胖表型的表现
RSC Adv. 2018 May 9;8(30):16957-16972. doi: 10.1039/c8ra00695d. eCollection 2018 May 3.
3
Impact of Genetic Risk Score and Dietary Protein Intake on Vitamin D Status in Young Adults from Brazil.遗传风险评分和膳食蛋白质摄入量对巴西年轻成年人维生素 D 状况的影响。
Nutrients. 2022 Feb 28;14(5):1015. doi: 10.3390/nu14051015.
4
The Effect of Polymorphisms of Energy Metabolism Genes on Metabolic Disorders in Overweight Adolescents of Two Ethnicities.两种族超重青少年能量代谢基因多态性对代谢紊乱的影响。
Bull Exp Biol Med. 2022 Feb;172(4):430-434. doi: 10.1007/s10517-022-05408-3. Epub 2022 Feb 17.
5
Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women.维生素 D 相关遗传风险评分与碳水化合物摄入对体脂肪成分的交互作用：东南亚米南卡保妇女的研究。
Nutrients. 2021 Jan 23;13(2):326. doi: 10.3390/nu13020326.
6
Association of the MC4R rs17782313 polymorphism with plasma ghrelin, leptin, IL6 and TNFα concentrations, food intake and eating behaviors in morbidly obese women.MC4R rs17782313 多态性与肥胖女性血浆 ghrelin、瘦素、IL6 和 TNFα 浓度、食物摄入和饮食行为的关联。
Eat Weight Disord. 2021 May;26(4):1079-1087. doi: 10.1007/s40519-020-01003-5. Epub 2020 Sep 11.
7
Selected neuropeptide genes show genetic differentiation between Africans and non-Africans.选定的神经肽基因在非洲人和非非洲人之间表现出基因分化。
BMC Genet. 2020 Mar 14;21(1):31. doi: 10.1186/s12863-020-0835-8.
8
Genetics of Obesity.肥胖的遗传学
Indian J Clin Biochem. 2016 Oct;31(4):361-71. doi: 10.1007/s12291-015-0541-x. Epub 2015 Dec 21.
9
Association of FTO rs9939609 SNP with Obesity and Obesity- Associated Phenotypes in a North Indian Population.FTO基因rs9939609单核苷酸多态性与北印度人群肥胖及肥胖相关表型的关联
Oman Med J. 2016 Mar;31(2):99-106. doi: 10.5001/omj.2016.20.
10
Nitric Oxide Exerts Basal and Insulin-Dependent Anorexigenic Actions in POMC Hypothalamic Neurons.一氧化氮在促黑素细胞激素原（POMC）下丘脑神经元中发挥基础和胰岛素依赖性的厌食作用。
Mol Endocrinol. 2016 Apr;30(4):402-16. doi: 10.1210/me.2015-1275. Epub 2016 Mar 1.

本文引用的文献

1
Evaluation of lifestyle of underweight, normal weight and overweight young women.体重过轻、正常体重和超重年轻女性的生活方式评估。
Coll Antropol. 2013 Jun;37(2):359-65.
2
Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children.GWAS 中鉴定的 11 个 BMI 相关基因座与中国儿童中心性肥胖的关联研究。
PLoS One. 2013;8(2):e56472. doi: 10.1371/journal.pone.0056472. Epub 2013 Feb 12.
3
Trends in waist circumference and central obesity in adults, northern iran.伊朗北部成年人腰围及中心性肥胖的趋势
Oman Med J. 2012 Jan;27(1):50-3. doi: 10.5001/omj.2012.10.
4
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier.FTO和MC4R基因变异与印度人肥胖特征的关联以及城乡环境作为潜在效应修饰因素的作用
J Obes. 2011;2011:307542. doi: 10.1155/2011/307542. Epub 2011 May 17.
5
Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth.FTO 和 INSIG2 及 MC4R 附近常见变异对非裔美国和欧洲裔美国青少年肥胖生长曲线的影响。
Eur J Epidemiol. 2011 Jun;26(6):463-73. doi: 10.1007/s10654-011-9583-4. Epub 2011 May 5.
6
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.对 249796 人的关联分析揭示了 18 个与体重指数相关的新位点。
Nat Genet. 2010 Nov;42(11):937-48. doi: 10.1038/ng.686. Epub 2010 Oct 10.
7
Dietary patterns only partially explain the effect of short sleep duration on the incidence of obesity.饮食模式只能部分解释睡眠不足对肥胖发生率的影响。
Sleep. 2010 Jun;33(6):753-7. doi: 10.1093/sleep/33.6.753.
8
Young healthy individuals develop lack of energy when adopting an obesity provoking behaviour for 4 weeks: a phenomenological analysis.年轻健康个体在采取诱发肥胖行为4周后会出现精力不足：一项现象学分析。
Scand J Caring Sci. 2010 Sep;24(3):565-71. doi: 10.1111/j.1471-6712.2009.00750.x.
9
Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population.从最近的全基因组关联研究中鉴定出的肥胖易感性遗传变异：在中国人群中的意义。
J Clin Endocrinol Metab. 2010 Mar;95(3):1395-403. doi: 10.1210/jc.2009-1465. Epub 2010 Jan 8.
10
Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.MC4R附近的变异与肥胖相关，并影响中年人群中与肥胖相关的数量性状：对14940名丹麦人的研究。
Diabetes. 2009 Mar;58(3):757-64. doi: 10.2337/db08-0620. Epub 2008 Dec 10.

印度北部MC4R基因[rs17782313、rs17700633]、AGRP基因[rs3412352]和POMC基因[rs1042571]多态性与肥胖的相关性评估

Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India.

作者信息

Srivastava Apurva, Mittal Balraj, Prakash Jai, Narain Varun Shanker, Natu S M, Srivastava Neena

机构信息

Department of Physiology, King George's Medical University, (Erstwhile Chhatrapati Shahuji Maharaj Medical University), Chowk, Lucknow, Uttar Pradesh, India 226003.

Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, Uttar Pradesh, India 226014.

出版信息

Oman Med J. 2014 Mar;29(2):114-8. doi: 10.5001/omj.2014.28.

DOI:10.5001/omj.2014.28
PMID:24715938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3976726/
Abstract

OBJECTIVE

Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity. Therefore, the aim of this study is to examine MC4R rs17782313, MC4R rs17700633, AGRP rs3412352 and POMCrs1042571 for any association with obesity in North Indian subjects.

METHODS

The variants were investigated for association in 300 individuals with BMI ≥30 kg/m(2) and 300 healthy non-obese individuals BMI <30 kg/m(2.) The genotyping were analyzed by Taqman probes. The statistical analysis was performed by the SPSS software, ver.19 and p≤0.05 was considered statistically significant.

RESULTS

The genotypes of MC4R rs17782313 and POMC rs1042571 were significantly associated with obesity (C), (p=0.02; OR=1.7 and p=0.01; OR=1.6, respectively); however, MC4Rrs17700633 (p=0.001; OR=0.55) was associated with low risk. In addition, AGRPrs3412352 (p=0.93; OR=0.96) showed no association with obesity (BMI ≥30 kg/m(2)) in North Indian subjects.

CONCLUSION

This study provides the report about the significant association of MC4R (rs17782313) and POMC (rs1042571) with morbid obesity (BMI ≥30 kg/m(2)), but MC4R (rs17700633) and AGRP (rs34123523) did not show any association with obesity in the studied North Indian population.

摘要

目的

据报道，黑皮质素-4受体基因（MC4R）、刺鼠相关蛋白（AGRP）和阿片促黑皮质素原（POMC）的基因变异与肥胖有关。因此，本研究旨在检测MC4R rs17782313、MC4R rs17700633、AGRP rs3412352和POMC rs1042571与北印度人群肥胖的相关性。

方法

对300名体重指数（BMI）≥30 kg/m²的个体和300名BMI<30 kg/m²的健康非肥胖个体进行基因变异相关性研究。采用Taqman探针进行基因分型分析。使用SPSS软件19版进行统计分析，p≤0.05被认为具有统计学意义。

结果

MC4R rs17782313和POMC rs1042571的基因型与肥胖显著相关（C，p=0.02；比值比[OR]=1.7；p=0.01；OR=1.6）；然而，MC4R rs17700633（p=0.001；OR=0.55）与低风险相关。此外，AGRP rs3412352（p=0.93；OR=0.96）在北印度人群中与肥胖（BMI≥30 kg/m²）无相关性。

结论

本研究报告了MC4R（rs17782313）和POMC（rs1042571）与病态肥胖（BMI≥30 kg/m²）的显著相关性，但在研究的北印度人群中，MC4R（rs17700633）和AGRP（rs34123523）与肥胖无相关性。