Taylor A E, Sandeep M N, Janipalli C S, Giambartolomei C, Evans D M, Kranthi Kumar M V, Vinay D G, Smitha P, Gupta V, Aruna M, Kinra S, Sullivan R M, Bowen L, Timpson N J, Davey Smith G, Dudbridge F, Prabhakaran D, Ben-Shlomo Y, Reddy K S, Ebrahim S, Chandak G R
School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.
J Obes. 2011;2011:307542. doi: 10.1155/2011/307542. Epub 2011 May 17.
Few studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as modifiers of these relationships. In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the aetiology of obesity is important. We investigated associations of FTO and MC4R variants with obesity traits in 3390 sibling pairs from four Indian cities, most of whom were discordant for current dwelling (rural or urban). The FTO variant rs9939609 predicted increased weight (0.09 Z-scores, 95% CI: 0.03, 0.15) and BMI (0.08 Z-scores, 95% CI: 0.02, 0.14). The MC4R variant rs17782313 was weakly associated with weight and hip circumference (P < .05). There was some indication that the association between FTO and weight was stronger in urban than that in rural dwellers (P for interaction = .03), but no evidence for effect modification by diet or physical activity. Further studies are needed to investigate ways in which urban environment may modify genetic risk of obesity.
很少有研究调查印度人群中基因变异与肥胖特征之间的关联，或环境因素作为这些关系调节因子的作用。在快速城市化导致生活方式发生重大变化的背景下，了解肥胖的病因很重要。我们在来自印度四个城市的3390对同胞对中调查了FTO和MC4R变异与肥胖特征的关联，其中大多数同胞对在当前居住环境（农村或城市）方面存在差异。FTO变异rs9939609预示着体重增加（0.09个Z分数，95%置信区间：0.03，0.15）和BMI增加（0.08个Z分数，95%置信区间：0.02，0.14）。MC4R变异rs17782313与体重和臀围呈弱关联（P < .05）。有迹象表明，FTO与体重之间的关联在城市居民中比在农村居民中更强（交互作用P值 = .03），但没有证据表明饮食或身体活动会产生效应修饰作用。需要进一步研究来调查城市环境可能改变肥胖遗传风险的方式。
