Karadjian Gregory, Berrebi Dominique, Dogna Nathalie, Vallarino-Lhermitte Nathaly, Bain Odile, Landau Irène, Martin Coralie
UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, 61 rue Buffon, CP 52, 75231 Paris Cedex 05, France.
Service d'Anatomie et de Cytologie Pathologique, Paris, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris France, and EA3102, Université Paris 7, France.
Parasite. 2014;21:16. doi: 10.1051/parasite/2014017. Epub 2014 Apr 10.
Infection with multiple parasite species is clearly the norm rather than the exception, in animals as well as in humans. Filarial nematodes and Plasmodium spp. are important parasites in human public health and they are often co-endemic. Interactions between these parasites are complex. The mechanisms underlying the modulation of both the course of malaria and the outcome of filarial infection are poorly understood. Despite increasing activity in recent years, studies comparing co- and mono-infections are very much in their infancy and results are contradictory at first sight. In this study we performed controlled and simultaneous co-infections of BALB/c mice with Litomosoides sigmodontis filaria and with Plasmodium spp. (Plasmodium yoelii 17 XNL or Plasmodium chabaudi 864VD). An analysis of pathological lesions in the kidneys and lungs and a parasitological study were conducted at different times of infection. Whatever the plasmodial species, the filarial recovery rate was strongly decreased. The peak of parasitaemia in the plasmodial infection was decreased in the course of P. yoelii infection but not in that of P. chabaudi. Regarding pathological lesions, L. sigmodontis can reverse lesions in the kidneys due to the presence of both Plasmodium species but does not modify the course of pulmonary lesions. The filarial infection induces granulomas in the lungs.
无论是在动物还是人类中，感染多种寄生虫物种显然是常态而非例外。丝虫线虫和疟原虫属是人类公共卫生中的重要寄生虫，它们常常共同流行。这些寄生虫之间的相互作用很复杂。疟疾病程和丝虫感染结果的调节机制目前还知之甚少。尽管近年来研究活动有所增加，但比较混合感染和单一感染的研究仍处于起步阶段，乍一看结果相互矛盾。在本研究中，我们对BALB/c小鼠进行了可控的同时混合感染，使其感染巴西日圆线虫丝虫和疟原虫属（约氏疟原虫17 XNL或查巴迪疟原虫864VD）。在感染的不同时间对肾脏和肺部的病理损伤进行了分析，并开展了寄生虫学研究。无论疟原虫种类如何，丝虫的回收率都大幅下降。在约氏疟原虫感染过程中，疟原虫感染的寄生虫血症峰值降低，但在查巴迪疟原虫感染过程中未降低。关于病理损伤，由于两种疟原虫的存在，巴西日圆线虫可逆转肾脏中的损伤，但不会改变肺部损伤的进程。丝虫感染会在肺部诱发肉芽肿。
