Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, 3156 Rampart Rd, Fort Collins, CO 80521, USA.
International Centre for Diarrheal Diseases Research, Bangladesh, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.
J Gen Virol. 2014 Jul;95(Pt 7):1436-1443. doi: 10.1099/vir.0.060764-0. Epub 2014 Apr 9.
Sunguru virus (SUNV), a novel virus belonging to the highly diverse Rhabdoviridae family, was isolated from a domestic chicken in the district of Arua, Uganda, in 2011. This is the first documented isolation of a rhabdovirus from a chicken. SUNV is related to, but distinct from, Boteke virus and other members of the unclassified Sandjimba group. The genome is 11056 nt in length and contains the five core rhabdovirus genes plus an additional C gene (within the ORF of a phosphoprotein gene) and a small hydrophobic protein (between the matrix and glycoprotein genes). Inoculation of vertebrate cells with SUNV resulted in significant viral growth, with a peak titre of 7.8 log10 p.f.u. ml(-1) observed in baby hamster kidney (BHK) cells. Little to no growth was observed in invertebrate cells and in live mosquitoes, with Anopheles gambiae mosquitoes having a 47.4% infection rate in the body but no dissemination of the virus to the salivary glands; this suggests that this novel virus is not arthropod borne as some other members of the family Rhabdoviridae.
桑格鲁病毒（SUNV）是一种新型病毒，属于高度多样化的 Rhabdoviridae 科，于 2011 年在乌干达阿鲁阿区的一只家鸡中分离出来。这是首次从鸡中分离出弹状病毒。SUNV 与博泰克病毒和其他未分类的桑吉姆巴群成员有关，但又有所不同。基因组长度为 11056 个核苷酸，包含五个核心 Rhabdoviridae 基因，加上一个额外的 C 基因（在磷蛋白基因的 ORF 内）和一个小的疏水蛋白（在基质蛋白和糖蛋白基因之间）。用 SUNV 接种脊椎动物细胞会导致显著的病毒生长，在仓鼠肾细胞（BHK）中观察到峰值滴度为 7.8log10p.f.u.ml(-1)。在无脊椎动物细胞和活体蚊子中几乎没有观察到生长，冈比亚按蚊在体内的感染率为 47.4%，但病毒没有传播到唾液腺；这表明这种新型病毒不像 Rhabdoviridae 科的其他一些成员那样是节肢动物传播的。
