London S D, Cebra J J, Rubin D H
Research Medicine, Veterans Administration Medical Center, Pennsylvania, Philadelphia 19104.
Microb Pathog. 1989 Jan;6(1):43-50. doi: 10.1016/0882-4010(89)90006-5.
Reovirus, a virus that contains neither an envelope nor glycosylated polypeptides, has been found to induce virus-specific, major histocompatibility complex (MHC) class I antigen restricted, cytotoxic T lymphocyte (CTL) responses. The cytotoxic T cells require in vitro stimulation in the presence of virus to phenotypically express cytotoxic activity. Utilizing reovirus types 1 and 3, the CTLs derived from mice infected with one serotype can lyse target cells infected with a second serotype of reovirus. In addition, lymphocytes primed in vivo with one serotype develop into fully functional CTLs during in vitro stimulation with the other serotype of reovirus. Therefore, these results suggest that reovirus induced CTLs are virus, but not serotype specific. Common determinants shared by reovirus polypeptides from reovirus types 1 and 3 are most likely the stimuli for the majority of CTLs responses to reovirus.
呼肠孤病毒是一种既无包膜也无糖基化多肽的病毒，已发现它能诱导病毒特异性、主要组织相容性复合体（MHC）I类抗原受限的细胞毒性T淋巴细胞（CTL）反应。细胞毒性T细胞需要在病毒存在的情况下进行体外刺激，以表型表达细胞毒性活性。利用1型和3型呼肠孤病毒，来自感染一种血清型的小鼠的CTL可以裂解感染另一种呼肠孤病毒血清型的靶细胞。此外，在体内用一种血清型致敏的淋巴细胞在体外受到另一种呼肠孤病毒血清型刺激时会发育成功能完全的CTL。因此，这些结果表明呼肠孤病毒诱导的CTL是病毒特异性的，而非血清型特异性的。1型和3型呼肠孤病毒多肽共有的共同决定簇很可能是大多数CTL对呼肠孤病毒反应的刺激因素。
