Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands; Euro Skin Bank, Beverwijk, The Netherlands.
Cell Immunol. 2014 May-Jun;289(1-2):49-54. doi: 10.1016/j.cellimm.2014.03.007. Epub 2014 Mar 27.
Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs). Here we investigated the effect of beta-glucan curdlan and the role of dectin-1 expressed by keratinocytes (KCs) in wound healing. Curdlan enhanced migration, proliferation and wound closure of human KCs in a dectin-1 dependent manner, both in vitro and ex vivo. Our data suggest that curdlan induces human KC proliferation and migration and could therefore be used in creams to enhance wound healing.
伤口敷料中的β-葡聚糖具有免疫刺激作用，已被证明可促进烧伤患者的伤口愈合。凝结多糖是一种 1,3 连接的细菌/真菌来源的β-葡聚糖，通过树突状细胞（DC）上的 C 型凝集素受体 dectin-1 诱导炎症反应。在这里，我们研究了β-葡聚糖凝结多糖的作用以及角质形成细胞（KC）表达的 dectin-1 在伤口愈合中的作用。凝结多糖以依赖于 dectin-1 的方式增强体外和离体培养的人 KC 的迁移、增殖和伤口闭合。我们的数据表明，凝结多糖诱导人 KC 的增殖和迁移，因此可用于乳膏中以增强伤口愈合。
