Bouzubar N, Walker K J, Griffiths K, Ellis I O, Elston C W, Robertson J F, Blamey R W, Nicholson R I
Tenovus Institute for Cancer Research, University of Wales College of Medicine, Health Park, Cardiff, UK.
Br J Cancer. 1989 Jun;59(6):943-7. doi: 10.1038/bjc.1989.200.
Ki67 immunostaining has been performed on 136 primary breast cancers and related to various clinical and pathological features of the disease. Staining was most frequently seen in poorly differentiated tumours showing high rates of mitotic activity, but was independent of tumour size, lymph-node status and ER expression. A high level of Ki67 immunostaining was often associated with early recurrence of breast cancer after mastectomy. These data are consistent with the concept of the Ki67 antibody detecting an antigen that is closely related to cell proliferation and thus provides a clinically useful marker for this important characteristic of the tumour.
已对136例原发性乳腺癌进行了Ki67免疫染色，并将其与该疾病的各种临床和病理特征相关联。染色最常见于显示有丝分裂活性率高的低分化肿瘤，但与肿瘤大小、淋巴结状态和雌激素受体（ER）表达无关。Ki67免疫染色水平高常与乳房切除术后乳腺癌的早期复发相关。这些数据与Ki67抗体检测到一种与细胞增殖密切相关的抗原的概念一致，因此为肿瘤的这一重要特征提供了一种临床有用的标志物。
