Zarzycki W
Endokrinologischen Klinik, Medizinischen Akademie in Białystok.
Dtsch Z Verdau Stoffwechselkr. 1988;48(5):229-38.
A single dose 0.2 U/kg b.w. of insulin was administrated after an hour of infusion of pentagastrin 2 micrograms/kg b.w. for 6 healthy volunteers aged about 27 (22-30); the investigation was carried out for 1.5 h. The control group consisted of 6 health volunteers aged about 27 (21-36) which were administrated infusion of pentagastrin. While applicating stimuli the gastric juice was aspirated for analysis. In 15-minutes fraction of gastric juice the volume, concentration and output of hydrochloric acid, pepsin, protein and carbohydrates components of gastric mucus: hexoses, hexosamine, fucose and sialic acid were measured. It was stated that insulin decreases gastric secretion stimulated by pentagastrin in two first 15-minutes fractions after administration of insulin dependently on decrease of gastric juice volume. Insulin-hypoglycemia is a stimulus decreasing gastric mucus secretion, stimulated by pentagastrin. On this ground the conclusion can be arrived, that pentagastrin evokes the mechanism decreasing gastric mucus secretion, probably adrenergic. Insulin does not change hydrochloric acid secretion, but it appears to be en extremely strong stimulus for pepsin secretion which proves hypothesis, that secretion of this enzyme is regulated mainly by vagus.
对6名年龄约27岁（22 - 30岁）的健康志愿者，在以2微克/千克体重输注五肽胃泌素1小时后，给予单次剂量0.2单位/千克体重的胰岛素；研究持续1.5小时。对照组由6名年龄约27岁（21 - 36岁）的健康志愿者组成，他们接受五肽胃泌素输注。施加刺激时，抽取胃液进行分析。在15分钟的胃液样本中，测量胃液的体积、盐酸、胃蛋白酶、蛋白质以及胃黏液中碳水化合物成分（己糖、氨基己糖、岩藻糖和唾液酸）的浓度和分泌量。结果表明，胰岛素给药后的前两个15分钟时间段内，胰岛素依赖于胃液体积的减少，降低了五肽胃泌素刺激的胃分泌。胰岛素低血糖是一种刺激，可减少五肽胃泌素刺激的胃黏液分泌。基于此可以得出结论，五肽胃泌素引发了可能是肾上腺素能的减少胃黏液分泌的机制。胰岛素不改变盐酸分泌，但它似乎是胃蛋白酶分泌的极强刺激因素，这证明了该酶的分泌主要由迷走神经调节的假设。
