Khor Chiew-Gek, Chen Xena Lung-Fang, Lin Ting-Syuan, Lu Cheng-Hsun, Hsieh Song-Chou
Rheumatology Unit, Department of Internal Medicine, Pulau Pinang General Hospital, Georgetown, Malaysia.
Clin Rheumatol. 2014 Jul;33(7):1019-20. doi: 10.1007/s10067-014-2579-1. Epub 2014 Apr 12.
Systemic sclerosis is an uncommon connective tissue disease characterised by excessive deposition of collagen and vasculopathy which affects the skin and multiple internal organs. It is associated with autoimmunity, inflammation, vasculopathy and fibrosis. Managing Raynaud's phenonemon, digital infarcts and ulcers in systemic sclerosis patients is often a challenge particularly among rheumatologists. We report a case of systemic sclerosis patient with refractory digital infarcts and ulcers responded successfully with rituximab.
系统性硬化症是一种罕见的结缔组织疾病，其特征是胶原蛋白过度沉积和血管病变，可影响皮肤和多个内脏器官。它与自身免疫、炎症、血管病变和纤维化有关。在系统性硬化症患者中，管理雷诺现象、指端梗死和溃疡往往是一项挑战，尤其是在风湿病学家中。我们报告了一例系统性硬化症患者，其难治性指端梗死和溃疡经利妥昔单抗治疗后成功缓解。
