Song Jinsoo, Kim Dongkyun, Han Jiyeon, Kim Yunha, Lee Myeungsu, Jin Eun-Jung
Department of Biological Sciences, College of Natural Sciences, Wonkwang University, Iksan, Chunbuk, 570-749, Korea.
Clin Exp Med. 2015 Feb;15(1):121-6. doi: 10.1007/s10238-013-0271-4. Epub 2014 Apr 11.
Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome of rheumatoid arthritis (RA) patients, leading the migration of active macrophage. In contrast, markedly lower level of Hotair was detected in differentiated osteoclasts and rheumatoid synoviocytes and enforced expression of Hotair led to significantly decreased levels of MMP-2 and MMP-13. This exploratory study provides novel empirical evidence that Hotair could be one of potential biomarkers for diagnosing RA.
尽管长链非编码RNA（lncRNAs）在正常生理和疾病状态下的重要性日益增加，但我们对类风湿关节炎（RA）相关lncRNAs的了解仍然有限。因此，我们旨在鉴定在RA中具有预后价值的lncRNA特征。在类风湿关节炎（RA）患者的血液单核细胞和血清外泌体中，Hotair的表达水平显著升高，导致活性巨噬细胞迁移。相反，在分化的破骨细胞和类风湿滑膜细胞中检测到Hotair水平明显较低，Hotair的过表达导致基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶-13（MMP-13）水平显著降低。这项探索性研究提供了新的经验证据，表明Hotair可能是诊断RA的潜在生物标志物之一。
