Division of Materials, Mechanics and Structures, Faculty of Engineering, ‡School of Chemistry, and §Process and Environmental Research Division, Faculty of Engineering, University of Nottingham , University Park, Nottingham NG7 2RD, United Kingdom.
Biomacromolecules. 2014 Apr 14;15(4):1498-506. doi: 10.1021/bm5001444. Epub 2014 Mar 28.
Polylactic acid (PLA) fibers were produced with an average diameter of 11.2 (± 0.9) μm via a melt-drawing process. The surface of the PLA fibers was coated with blends of cellulose nanowhiskers (CNWs) (65 to 95 wt %) and polyvinyl acetate (PVAc). The CNWs bound to the smooth PLA fiber surface imparted roughness, with the degree of roughness depending on the coating blend used. The fiber tensile modulus increased 45% to 7 GPa after coating with 75 wt % CNWs compared with the uncoated PLA fibers, and a significant increase in the fiber moisture absorption properties at different humidity levels was also determined. Cytocompatibility studies using NIH-3T3 mouse fibroblast cells cultured onto CNWs-coated PLA surface revealed improved cell adhesion compared with the PLA control, making this CNW surface treatment applicable for biomedical and tissue engineering applications. Initial studies also showed complete cell coverage within 2 days.
聚乳酸（PLA）纤维的平均直径为 11.2（±0.9）μm，通过熔融拉伸工艺生产。PLA 纤维的表面涂覆有纤维素纳米纤维（CNWs）（65 至 95 重量%）和聚醋酸乙烯酯（PVAc）的混合物。CNWs 与光滑的 PLA 纤维表面结合，赋予其粗糙度，其粗糙度程度取决于所用的涂层混合物。与未涂层的 PLA 纤维相比，用 75 重量%的 CNWs 涂层后，纤维的拉伸模量增加了 45%至 7 GPa，并且还确定了在不同湿度水平下纤维吸湿性能的显著提高。使用 NIH-3T3 小鼠成纤维细胞在 CNWs 涂层 PLA 表面上进行的细胞相容性研究表明，与 PLA 对照相比，细胞粘附得到改善，使得这种 CNW 表面处理适用于生物医学和组织工程应用。初步研究还表明，在 2 天内即可实现完全细胞覆盖。
