Departments of Medicine, Biochemistry, and Genetics, Center for Science, Health and Society, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Ann N Y Acad Sci. 2014 Apr;1311:57-76. doi: 10.1111/nyas.12416.
Overweight and obesity have reached pandemic levels on a worldwide basis and are associated with increased risk and worse prognosis for many but not all malignancies. Pathophysiologic processes that affect this association are reviewed, with a focus on the relationship between type 2 diabetes mellitus and cancer, lessons learned from the use of murine models to study the association, the impact of obesity on pancreatic cancer, the effects of dietary fats and cholesterol on cancer promotion, and the mechanisms by which the intestinal microbiome affects obesity and cancer.
超重和肥胖已在全球范围内达到流行水平，并与许多（而非全部）恶性肿瘤的风险增加和预后恶化相关。本文回顾了影响这种关联的病理生理过程，重点关注 2 型糖尿病与癌症之间的关系、从使用鼠模型研究这种关联中吸取的经验教训、肥胖对胰腺癌的影响、膳食脂肪和胆固醇对癌症促进的作用，以及肠道微生物组影响肥胖和癌症的机制。
