Beranek J T
Service des Maladies Sanduines, Immunitaires et Tumorales, Hôpital Paul-Brousse, Villejuif, France.
Med Hypotheses. 1989 Apr;28(4):271-3. doi: 10.1016/0306-9877(89)90082-0.
According to the conventional hypothesis and its variants, wound granulation tissue is formed by the proliferation and the migration of two closely cooperating but separated cell systems: the endothelial and the fibroblastic (including pericytes). While the elaborated theory of angiogenesis explains the former, there is not a similar theory concerning the latter. The recently proposed angiogenic hypothesis of repair and fibrosis unifies both cell systems by proposing endothelial origin for fibroblastic cells. It was formed on the basis of hyperplastic capillaries and vascular endothelium derived fibroblastic cells in chronic fibrotic diseases. The recent description of hyperplastic capillary sprouts in experimental fibrin clots confirms the validity of this hypothesis also in healing by primary and secondary intentions.
根据传统假说及其变体，伤口肉芽组织由两个密切协作但相互分离的细胞系统增殖和迁移形成：内皮细胞系统和成纤维细胞系统（包括周细胞）。虽然详尽的血管生成理论解释了前者，但关于后者却没有类似的理论。最近提出的修复和纤维化血管生成假说通过提出成纤维细胞起源于内皮细胞，将这两个细胞系统统一起来。它是基于慢性纤维化疾病中增生的毛细血管和血管内皮衍生的成纤维细胞形成的。最近对实验性纤维蛋白凝块中增生性毛细血管芽的描述也证实了这一假说在一期和二期愈合中的有效性。
