McGeorge A J, Faull R L
Department of Anatomy, University of Auckland, New Zealand.
Neuroscience. 1989;29(3):503-37. doi: 10.1016/0306-4522(89)90128-0.
The detailed organization of the corticostriate projection has been investigated in the brain of the rat using the technique of retrograde transport of horseradish peroxidase following the placement of small, iontophoretic injections of horseradish peroxidase conjugated to lectin throughout all major regions of the striatum (caudate-putamen, nucleus accumbens and olfactory tubercle). The results demonstrate that all major regions of the cerebral cortex project to the striatum on both sides of the brain with an ipsilateral predominance. The cells of origin of both the ipsilateral and contralateral corticostriate projections lie mainly in lamina V (especially lamina Va) with very small numbers in lamina III of the neocortex and mesocortex, and in the deep laminae of the allocortex. The results show that each striatal locus receives inputs from several cortical regions, i.e. there is extensive overlap in the corticostriate projection, and that, in general terms, each cortical region projects onto a longitudinally oriented region of the striatum. In particular, the major subdivisions of the cerebral cortex--the neocortex, mesocortex and allocortex--project onto defined but partially overlapping regions of the striatum: the neocortex projects to the caudate-putamen; the mesocortex projects mainly to the medial and ventral regions of the caudate-putamen but also to the ventral striatum (nucleus accumens and olfactory tubercle); and the allocortex projects mainly to the ventral striatum but also to the medial and ventral parts of the caudate-putamen. Within each of these major projection systems there is a further organization, with the constituent parts of each major cortical region projecting to smaller longitudinal components of the major projection fields. Each neocortical area projects to a longitudinal region of the dorsal striatum (caudate-putamen): the sensory and motor areas project topographically onto the dorsolateral striatum such that the rostral sensorimotor cortex (head areas) projects to central and ventral regions and the more caudal sensorimotor cortex (limb areas) projects to dorsal regions of the dorsolateral striatum; the visual area projects to the dorsomedial striatum; and the auditory area projects to the medial striatum. Each mesocortical area projects to a longitudinal area of the striatum: the most posteromedial mesocortex (the retrosplenial area) projects to the dorsomedial striatum; more anterior and lateral parts of the mesocortex project to more ventral parts of the striatum: and the most lateral mesocortex (the agranular insular and perirhinal areas) project to the ventrolateral striatum.(ABSTRACT TRUNCATED AT 400 WORDS)
运用辣根过氧化物酶逆行运输技术，在大鼠脑内研究了皮质纹状体投射的详细组织情况。该技术是在纹状体所有主要区域（尾状核 - 壳核、伏隔核和嗅结节）进行小剂量离子电渗注射结合凝集素的辣根过氧化物酶。结果表明，大脑皮质的所有主要区域均向脑两侧的纹状体投射，且同侧投射占优势。同侧和对侧皮质纹状体投射的起源细胞主要位于第V层（尤其是第Va层），新皮质和中皮质的第III层以及原皮质深层中的细胞数量极少。结果显示，每个纹状体位点都接收来自多个皮质区域的输入，即皮质纹状体投射存在广泛重叠，并且一般来说，每个皮质区域投射到纹状体的一个纵向区域。特别是，大脑皮质的主要亚区——新皮质、中皮质和原皮质——投射到纹状体中特定但部分重叠的区域：新皮质投射到尾状核 - 壳核；中皮质主要投射到尾状核 - 壳核的内侧和腹侧区域，但也投射到腹侧纹状体（伏隔核和嗅结节）；原皮质主要投射到腹侧纹状体，但也投射到尾状核 - 壳核的内侧和腹侧部分。在这些主要投射系统的每一个中都存在进一步的组织，每个主要皮质区域的组成部分投射到主要投射场的较小纵向成分。每个新皮质区域投射到背侧纹状体（尾状核 - 壳核）的一个纵向区域：感觉和运动区域按拓扑结构投射到背外侧纹状体，使得吻侧感觉运动皮质（头部区域）投射到中央和腹侧区域，而更尾侧的感觉运动皮质（肢体区域）投射到背外侧纹状体背侧区域；视觉区域投射到背内侧纹状体；听觉区域投射到内侧纹状体。每个中皮质区域投射到纹状体的一个纵向区域：最靠后内侧的中皮质（压后皮质区域）投射到背内侧纹状体；中皮质更靠前和外侧的部分投射到纹状体更腹侧的部分；最外侧的中皮质（无颗粒岛叶和嗅周区域）投射到腹外侧纹状体。（摘要截选至400字）
