植物天然产物生物合成的化学逻辑。
The chemical logic of plant natural product biosynthesis.
作者信息
Anarat-Cappillino Gülbenk, Sattely Elizabeth S
机构信息
Department of Chemical Engineering, Stanford University, Stanford, CA 94305, United States.
Department of Chemical Engineering, Stanford University, Stanford, CA 94305, United States.
出版信息
Curr Opin Plant Biol. 2014 Jun;19:51-8. doi: 10.1016/j.pbi.2014.03.007. Epub 2014 Apr 14.
Abstract
Understanding the logic of plant natural product biosynthesis is important for three reasons: it guides the search for new natural products and pathways, illuminates the function of existing pathways in the context of host biology, and builds an enabling 'parts list' for plant and microbial metabolic engineering. In this review, we highlight the chemical themes that underlie a broad range of plant pathways, dividing pathways into two parts: scaffold-generating steps that draw on a limited set of chemistries, and tailoring reactions that produce a wide range of end products from a small number of common scaffolds.
摘要
了解植物天然产物生物合成的逻辑很重要，原因有三：它指导寻找新的天然产物和途径，阐明宿主生物学背景下现有途径的功能，并为植物和微生物代谢工程构建一个有利的“元件清单”。在本综述中，我们强调了广泛的植物途径所基于的化学主题，将这些途径分为两部分：利用有限化学类型的骨架生成步骤，以及从少量常见骨架产生多种终产物的修饰反应。
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