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发育性语言障碍中的神经病理学异常。

Neuropathological abnormalities in developmental dysphasia.

作者信息

Cohen M, Campbell R, Yaghmai F

机构信息

Department of Neurology, Medical College of Georgia, Augusta 30912.

出版信息

Ann Neurol. 1989 Jun;25(6):567-70. doi: 10.1002/ana.410250607.

DOI:10.1002/ana.410250607
PMID:2472772
Abstract

The brain of a 7-year-old girl with developmental dysphasia who died of complications of infectious mononucleosis was examined grossly and histologically. The neuropathological studies revealed atypical symmetry of the plana temporale and a dysplastic gyrus on the inferior surface of the left frontal cortex along the inferior surface of the sylvian fissure. These anomalies are likely related to midgestation, the period of neuronal migration from the germinal matrix to the cerebral cortex, and are consistent with a neurodevelopmental cause of developmental dysphasia.

摘要

对一名因传染性单核细胞增多症并发症死亡的7岁发育性语言障碍女孩的大脑进行了大体和组织学检查。神经病理学研究显示颞平面存在非典型对称性,以及沿外侧裂下表面的左额叶皮质下表面有一个发育异常的脑回。这些异常可能与妊娠中期有关,即神经元从生发基质迁移到大脑皮质的时期,并且与发育性语言障碍的神经发育原因一致。

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