Zöller E
Universitäts-HNO-Klinik Essen.
Laryngorhinootologie. 1989 Jun;68(6):358-60. doi: 10.1055/s-2007-998353.
Inflammatory diseases may lead to local tissue injury due to an imbalance between leukocyte elastase and protease inhibitors (alpha-1-antitrypsin, alpha-2-macroglobulin). Hence, we determined the plasma level of elastase in patients with chronic tonsillitis using an enzyme-linked immunoassay and compared the results with those obtained from controls. There was a significant elevation of leukocyte elastase in patients with chronic inflammation of the tonsils compared with our controls. The sensitivity and specificity of the elastase assay characterise this method as a reliable one. Hence, the determination of leukocyte elastase in peripheral blood can be useful if the indication for tonsillectomy is in question.
炎症性疾病可能由于白细胞弹性蛋白酶和蛋白酶抑制剂（α-1抗胰蛋白酶、α-2巨球蛋白）之间的失衡而导致局部组织损伤。因此，我们使用酶联免疫吸附测定法测定了慢性扁桃体炎患者血浆中的弹性蛋白酶水平，并将结果与对照组进行了比较。与我们的对照组相比，扁桃体慢性炎症患者的白细胞弹性蛋白酶水平显著升高。弹性蛋白酶测定的敏感性和特异性表明该方法是可靠的。因此，当扁桃体切除术的指征存在疑问时，测定外周血中的白细胞弹性蛋白酶可能会有所帮助。
