Zheng Jianmao, Mao Xueli, Ling Junqi, He Qun, Quan Jingjing, Jiang Hongbo
Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Affiliated Stomatological Hospital, Sun Yat-sen University, Guangzhou, 510055, Guangdong, China.
Biol Trace Elem Res. 2014 Jun;159(1-3):8-14. doi: 10.1007/s12011-014-9961-3. Epub 2014 Apr 12.
There are conflicting reports as to the association between serum level of magnesium (Mg) and postmenopausal osteoporosis (OP). The purpose of the present study is to clarify the association between serum level of Mg and postmenopausal OP using a meta-analysis approach. We searched articles indexed in Pubmed and the Chinese Journal Full-text Database (CJFD) published as of October 2013 that met our predefined criteria. Seven eligible studies involving 1,349 postmenopausal women from 12 case-control study arms were identified. Overall, pooled analysis indicated that postmenopausal osteoporotic women had a lower serum level of Mg than the healthy controls (standardized mean difference [SMD]=-0.55, 95 % confidence interval [CI]=-0.83 to -0.26). Further subgroup analysis found a similar pattern in Turkey (SMD=-0.66, 95% CI=-0.99 to -0.32) and Belgium (SMD=-0.98, 95% CI=-1.91 to -0.05), but not in China (SMD=0.02, 95% CI=-0.21 to 0.26). And the difference of serum level of Mg between postmenopausal osteoporotic women and healthy controls below the age of 60 years (SMD=-0.61, 95% CI=-1.09 to -0.13) was similar to that among the population over 60 years (SMD=-0.49, 95% CI=-0.80 to -0.18).In conclusion, this meta-analysis suggests that the low serum level of Mg seems to be a risk factor for OP among the postmenopausal women. However, the subgroup analysis found that there was contradiction regarding races and geography, like China and Turkey. Thus, this finding needs further confirmation by trans-regional multicenter study to obtain better understanding of causal relationships between serum Mg and postmenopausal OP.
关于血清镁（Mg）水平与绝经后骨质疏松症（OP）之间的关联，存在相互矛盾的报道。本研究的目的是采用荟萃分析方法阐明血清镁水平与绝经后OP之间的关联。我们检索了截至2013年10月发表在Pubmed和中国期刊全文数据库（CJFD）中符合我们预先定义标准的文章。确定了7项符合条件的研究，涉及来自12个病例对照研究组的1349名绝经后妇女。总体而言，汇总分析表明，绝经后骨质疏松症妇女的血清镁水平低于健康对照组（标准化均值差[SMD]=-0.55，95%置信区间[CI]=-0.83至-0.26）。进一步的亚组分析发现，土耳其（SMD=-0.66，95%CI=-0.99至-0.32）和比利时（SMD=-0.98，95%CI=-1.91至-0.05）呈现出类似模式，但中国并非如此（SMD=0.02，95%CI=-0.21至0.26）。并且60岁以下绝经后骨质疏松症妇女与健康对照组之间血清镁水平的差异（SMD=-0.61，95%CI=-1.09至-0.13）与60岁以上人群的差异相似（SMD=-0.49，95%CI=-0.80至-0.18）。总之，这项荟萃分析表明，血清镁水平低似乎是绝经后妇女患OP的一个危险因素。然而，亚组分析发现，在种族和地理方面存在矛盾，如中国和土耳其。因此，这一发现需要通过跨地区多中心研究进一步证实，以更好地理解血清镁与绝经后OP之间的因果关系。
