Zheng Jianmao, Mao Xueli, Ling Junqi, He Qun, Quan Jingjing
Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Affiliated Stomatological Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Biol Trace Elem Res. 2014 Jul;160(1):15-23. doi: 10.1007/s12011-014-0031-7. Epub 2014 Jun 8.
Zinc (Zn), copper (Cu), and iron (Fe) are essential trace elements for the growth, development, and maintenance of healthy bones. However, there are conflicting reports as to the relationship between serum level of Zn, Cu, or Fe and osteoporosis (OP). The purpose of the present study is to clarify the relationship between serum Zn, Cu, or Fe and OP using a meta-analysis approach. We searched all articles indexed in PubMed published up to May 2014 concerning the association between serum level of Zn, Cu, or Fe and OP. Eight eligible articles involving 2,188 subjects were identified. Overall, pooled analysis indicated that patients with OP had a lower serum level of Zn, Cu, or Fe than the healthy controls (Zn standardized mean difference (SMD) = -1.396, 95% confidence interval (CI) = [-2.129, -0.663]; Cu SMD = -0.386, 95% CI = [-0.538, -0.234]; Fe SMD = -0.22, 95% CI = [-0.30, -0.13]). Further subgroup analysis found that geographical location and gender had an influence on the serum level of Zn in OP and healthy controls, but not on the serum level of Cu or Fe. No evidence of publication bias was observed. In conclusion, this meta-analysis suggests that low serum levels of Zn, Cu, and Fe seem to be important risk factors for OP and well-designed studies with adequate control for confounding factors are required in future investigations.
锌（Zn）、铜（Cu）和铁（Fe）是骨骼生长、发育和维持健康所必需的微量元素。然而，关于血清锌、铜或铁水平与骨质疏松症（OP）之间的关系，存在相互矛盾的报道。本研究的目的是采用荟萃分析方法阐明血清锌、铜或铁与OP之间的关系。我们检索了截至2014年5月在PubMed上索引的所有关于血清锌、铜或铁水平与OP之间关联的文章。确定了8篇符合条件的文章，涉及2188名受试者。总体而言，汇总分析表明，OP患者的血清锌、铜或铁水平低于健康对照组（锌的标准化平均差（SMD）=-1.396，95%置信区间（CI）=[-2.129，-0.663]；铜的SMD=-0.386，95%CI=[-0.538，-0.234]；铁的SMD=-0.22，95%CI=[-0.30，-0.13]）。进一步的亚组分析发现，地理位置和性别对OP患者和健康对照组的血清锌水平有影响，但对血清铜或铁水平没有影响。未观察到发表偏倚的证据。总之，这项荟萃分析表明，血清锌、铜和铁水平低似乎是OP的重要危险因素，未来的研究需要设计良好且对混杂因素有充分控制的研究。
