Saadeh Yamaan, Leung Tiffany, Vyas Arpita, Chaturvedi Lakshmi Shankar, Perumal Omathanu, Vyas Dinesh
J Nanosci Nanotechnol. 2014 Jan;14(1):913-23. doi: 10.1166/jnn.2014.8755.
Worldwide, breast cancer remains as one of the most common cancer diagnosis and cause of cancer related death among women. Fortunately, nanomedicine has brought forth new potential and hope in breast cancer research. The extremely small size of nanoparticles makes it advantageous and potentially superior to use in tumor detection and imaging. One of the more extensively studied particles is quantum dots, semiconductor crystals which are capable of enhanced labeling and imaging of cancer cells. In addition, due to serious toxicity of chemotherapeutic agents, nano-formulations of breast cancer chemotherapy are under investigation and development. This may provide easier administering route and reduced frequency of drugs. With the use of nanoparticles, drug delivery can be carried out in a minimally invasive fashion and treatment regimens can be made much more targeted and specific for each patient. In this review article, we provide an overview on the role nanomedicine has played in breast cancer and mention some of the latest diagnostic and treatment modalities researched to date.
在全球范围内，乳腺癌仍然是女性中最常见的癌症诊断类型之一，也是癌症相关死亡的主要原因。幸运的是，纳米医学为乳腺癌研究带来了新的潜力和希望。纳米颗粒的极小尺寸使其在肿瘤检测和成像方面具有优势，并且可能更具优越性。量子点是研究较为广泛的颗粒之一，它是一种半导体晶体，能够增强对癌细胞的标记和成像。此外，由于化疗药物的严重毒性，乳腺癌化疗的纳米制剂正在研究和开发中。这可能提供更简便的给药途径并减少用药频率。通过使用纳米颗粒，可以以微创方式进行药物递送，并且治疗方案可以针对每个患者制定得更具针对性和特异性。在这篇综述文章中，我们概述了纳米医学在乳腺癌中所起的作用，并提及了迄今为止研究的一些最新诊断和治疗方式。
