Division of Cardiology, Department of Medicine, Emory University , Atlanta, Georgia .
Antioxid Redox Signal. 2014 Jun 10;20(17):2692-4. doi: 10.1089/ars.2014.5947.
From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemistry, the multiple cellular functions controlled by NADPH oxidases, and their varied roles in physiology and diseases. We have developed numerous cell culture tools, animal models, and human databases that have allowed us to delve deeply into the various roles of these enzymes. However, it is clear that much remains to be learned and that there are many opportunities for new tools and new research directions to more fully understand these critical enzymes. With this Antioxidants and Redox Signaling Forum, we explore in detail the progress, challenges, and opportunities in Nox biology. Progress so far has clearly shown that NADPH oxidases are integral to fully functioning organisms and that the dysregulation of Nox enzymes contributes to a wide variety of pathologies. We have the opportunity to develop new tools and small molecules that will not only help us to better understand the molecular underpinnings of NADPH oxidases but also to develop treatments for diverse human diseases.
从 1999 年首次发现 NADPH 氧化酶家族包含一系列酶，到我们目前专注于开发药物来治疗与该酶家族相关的多种病理，进展迅速且令人印象深刻。我们已经扩展了对家族范围、基本酶生化、NADPH 氧化酶控制的多种细胞功能以及它们在生理学和疾病中的不同作用的理解。我们开发了许多细胞培养工具、动物模型和人类数据库，使我们能够深入研究这些酶的各种作用。然而，显然还有很多需要学习的，并且有许多机会开发新的工具和新的研究方向，以更全面地了解这些关键酶。通过这个抗氧化剂和氧化还原信号论坛，我们详细探讨了 Nox 生物学的进展、挑战和机遇。迄今为止的进展清楚地表明，NADPH 氧化酶是功能齐全的生物体的组成部分，Nox 酶的失调会导致多种病理。我们有机会开发新的工具和小分子，这不仅将帮助我们更好地理解 NADPH 氧化酶的分子基础，还将为各种人类疾病开发治疗方法。
