Kieber-Emmons T, Ward R E, Raychaudhuri S, Rein R, Kohler H
Department of Molecular Immunology, Roswell Park Memorial Institute, Buffalo, New York 14263.
Int Rev Immunol. 1986 Jan;1(1):1-26. doi: 10.3109/08830188609056598.
Current emphasis on risk factors associated with established vaccines and pressing needs for vaccines against certain viral transmitted diseases have stimulated the search for new conceptual and practical approaches to vaccine production. Among these developments, the idiotope vaccine method has produced promising results. In this review the basic and conceptual principles for idiotype vaccine design are discussed. A novel approach for identifying idiotopic structures in the three dimensional structure of internal idiotope antigens is developed. The method is based on the relationship of the immune response with the evolutionary variation and diversity of the immunoglobulin family. Idiotopic structures are found in specialized topographic regions on the surface of the immunoglobulin molecule. The knowledge of these idiotope domains will facilitate the synthesis of idiotope expressing peptides and the computer modeling of the three dimensional structure of internal idiotope antigens. Finally, the existing evidence for successful application of the idiotope vaccine method is summarized and new disease groups are identified which could benefit from the development of idiotope vaccines.
当前对与现有疫苗相关的风险因素的重视以及对针对某些病毒传播疾病的疫苗的迫切需求，刺激了人们寻找新的疫苗生产概念和实用方法。在这些进展中，独特型疫苗方法取得了有前景的成果。在这篇综述中，讨论了独特型疫苗设计的基本和概念原则。开发了一种在内部独特型抗原三维结构中识别独特型结构的新方法。该方法基于免疫反应与免疫球蛋白家族进化变异和多样性的关系。独特型结构存在于免疫球蛋白分子表面的特定拓扑区域。这些独特型结构域的知识将有助于合成表达独特型的肽以及对内部独特型抗原三维结构进行计算机建模。最后，总结了独特型疫苗方法成功应用的现有证据，并确定了可能从独特型疫苗开发中受益的新疾病群体。
