急性心肌梗死患者的血清阿德罗皮素水平降低。
Serum adropin levels are decreased in patients with acute myocardial infarction.
作者信息
Yu Hou-you, Zhao Peng, Wu Ming-chun, Liu Jian, Yin Wen
机构信息
Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an 710032, PR China.
Department of Anaesthiology, Wuhan general Hospital of Guangzhou Command, No. 627 Wuluo Road, Wuhan, 430070, PR China.
出版信息
Regul Pept. 2014 May;190-191:46-9. doi: 10.1016/j.regpep.2014.04.001. Epub 2014 Apr 13.
OBJECTIVE
Adropin is a recently identified bioactive protein that is important for energy homeostasis and maintaining insulin sensitivity. We sought to detect serum adropin levels in acute myocardial infarction (AMI) patients.
METHODS
We enrolled 138 AMI patients, 114 stable angina pectoris (SAP) patients and 75 controls. Adropin levels were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS
Serum adropin levels were significantly lower in patients with AMI compared with SAP patients or controls (P<0.01). Multivariate logistic regression demonstrated that lower adropin was the independent predictor for the presence of AMI in coronary artery disease (CAD) patients (P<0.01). Serum adropin levels were negatively associated with body mass index (BMI) (P<0.01) and triglyceride levels (P<0.05) in AMI patients.
CONCLUSION
Decreased serum adropin levels are associated with the presence of AMI in CAD patients. These results revealed that adropin might represent as a novel biomarker for predicting AMI onset in CAD patients.
目的
内脂素是一种最近发现的生物活性蛋白，对能量平衡和维持胰岛素敏感性很重要。我们试图检测急性心肌梗死（AMI）患者的血清内脂素水平。
方法
我们纳入了138例AMI患者、114例稳定型心绞痛（SAP）患者和75例对照。采用酶联免疫吸附测定（ELISA）法测量内脂素水平。
结果
与SAP患者或对照相比，AMI患者的血清内脂素水平显著降低（P<0.01）。多因素逻辑回归显示，较低的内脂素是冠状动脉疾病（CAD）患者发生AMI的独立预测因素（P<0.01）。AMI患者的血清内脂素水平与体重指数（BMI）（P<0.01）和甘油三酯水平（P<0.05）呈负相关。
结论
CAD患者血清内脂素水平降低与AMI的发生有关。这些结果表明，内脂素可能是预测CAD患者AMI发病的一种新型生物标志物。
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