血清阿杜林水平与冠状动脉疾病的相关性

[Correlation of serum adropin level with coronary artery disease].

作者信息

Zhang Chengjia, Zhao Liangping, Xu Weiting, Li Jianfeng, Wang Bing, Gu Xiaosong, Chen Jianchang

机构信息

Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.

Department of Cardiology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China. Email:

出版信息

Zhonghua Yi Xue Za Zhi. 2014 Apr 29;94(16):1255-7.

PMID:24924892

Abstract

OBJECTIVE

To explore the correlation of serum adropin level with coronary artery disease (CAD).

METHODS

According to coronary angiography, 356 consecutive patients with chest complaints from January 2011 to July 2012 were divided into 2 groups of CAD (n = 264, with CAD) and control (n = 92, without CAD). The serum adropin level and other CAD related metabolic parameters were measured and SYNTAX score was calculated.

RESULTS

Serum adropin level was significantly lower in group CAD than that in control group ((56 ± 15) vs (83 ± 10) ng/L, P < 0.01).Serum adropin levels in high, mild, low SYNTAX score group were (60 ± 22),(56 ± 12),(54 ± 10) ng/L respectively, and there was no significant difference among 3 groups(P = 0.116). Multivariate regression analysis revealed that adropin was an independent risk factor for CAD (OR = 0.849, 95%CI:0.817-0.882, P < 0.01).

CONCLUSIONS

Lower serum adropin level is significantly associated with CAD. Thus it indicates a possible role of adropin in the prevention of CAD.

摘要

目的

探讨血清内脂素水平与冠状动脉疾病（CAD）的相关性。

方法

根据冠状动脉造影结果，将2011年1月至2012年7月期间连续收治的356例有胸痛症状的患者分为CAD组（n = 264，患有CAD）和对照组（n = 92，未患CAD）。检测血清内脂素水平及其他与CAD相关的代谢参数，并计算SYNTAX评分。

结果

CAD组血清内脂素水平显著低于对照组（（56±15）对（83±10）ng/L，P < 0.01）。高、中、低SYNTAX评分组的血清内脂素水平分别为（60±22）、（56±12）、（54±10）ng/L，三组间差异无统计学意义（P = 0.116）。多因素回归分析显示，内脂素是CAD的独立危险因素（OR = 0.849，95%CI：0.817 - 0.882，P < 0.01）。