Takahashi H, Tsuda N, Tezuka F, Okabe H
Department of Oral Pathology, Nagasaki University School of Dentistry, Japan.
J Oral Pathol Med. 1989 Feb;18(2):84-91. doi: 10.1111/j.1600-0714.1989.tb00742.x.
Seventy cases (47M, 23F) of primary extranodal non-Hodgkin's lymphoma of the oral region were studied to determine tumor characteristics. The most frequent disease sites were the palate (21 cases), gingiva (17 cases) and parotid gland (13 cases). Each lymphoma was classified according to the criteria of the Working Formulation for Clinical Usage. Only 5.7% of cases were follicular lymphomas while diffuse lymphomas had a high incidence. Histologic subtypes included small lymphocytic (1%), small cleaved cell (7%), mixed small and large cell (20%), large cell (43%), large cell, immunoblastic (17%), lymphoblastic (9%) and small non-cleaved cell lymphoma (3%). Immunologic study utilizing the avidin-biotinylated horseradish peroxidase complex (ABC) technique demonstrated the presence of intracytoplasmic monoclonal immunoglobulin in 24 (34%) of the suggested B-cell lymphoma cases; 20 tumors (28%) were classified as T-cell lymphoma based on a positive reaction for mouse monoclonal antibody (UCHL-1) to T-cell related membrane antigen; 11 tumors (16%) contained intracytoplasmic alpha 1-antitrypsin, suggesting true histiocytic lymphoma; 15 tumors (22%) did not contain immunoglobulin, UCHL-1 or alpha 1-antitrypsin positive cells and showed no definite characteristics.
对70例口腔原发性结外非霍奇金淋巴瘤患者（47例男性，23例女性）进行研究以确定肿瘤特征。最常见的发病部位是腭部（21例）、牙龈（17例）和腮腺（13例）。每例淋巴瘤均根据临床应用工作分类标准进行分类。仅5.7%的病例为滤泡性淋巴瘤，而弥漫性淋巴瘤发病率较高。组织学亚型包括小淋巴细胞型（1%）、小裂细胞型（7%）、小细胞与大细胞混合型（20%）、大细胞型（43%）、大细胞免疫母细胞型（17%）、淋巴母细胞型（9%）和小无裂细胞淋巴瘤（3%）。利用抗生物素蛋白-生物素化辣根过氧化物酶复合物（ABC）技术进行的免疫学研究显示，在24例（34%）疑似B细胞淋巴瘤病例的细胞浆内存在单克隆免疫球蛋白；20个肿瘤（28%）基于对T细胞相关膜抗原的小鼠单克隆抗体（UCHL-1）呈阳性反应而被分类为T细胞淋巴瘤；11个肿瘤（16%）含有细胞浆内α1-抗胰蛋白酶，提示为真性组织细胞淋巴瘤；15个肿瘤（22%）不含免疫球蛋白、UCHL-1或α1-抗胰蛋白酶阳性细胞，且无明确特征。
