Manjunatha B S, Gowramma R, Nagarajappa D, Tanveer Ahmed
Department of Oral Pathology and Microbiology, K M Shah Dental College and Hospital, Vadodara, Gujarat, India.
J Indian Soc Periodontol. 2011 Oct;15(4):418-20. doi: 10.4103/0972-124X.92584.
Non-Hodgkin's lymphoma (NHL) commonly presents as non-tender, enlarged lymph nodes, accompanied by diffuse symptoms of fatigue and low-grade intermittent fever and it is derived predominantly from the cells of the B lymphocyte series. NHL cases occur extra-nodally and in 3% of these cases the initial presentation may be in the oral cavity. Though extra-nodal NHL of the oral cavity is a rare finding, patients with oral lesions of NHL commonly present at the dental clinic in the first instance. A careful clinical evaluation supported by histopathological and other laboratory investigations will help in identifying the disease at an early stage, resulting in better prognosis. Any delay in diagnosis has important implications on the morbidity and mortality of the condition. Due to the rarity of intraoral NHL, we present one such a case with a complaint of tumor-like mass on the gingiva of lower molar region. The lesion was clinically thought as pyogenic granuloma and later diagnosed as extra nodal NHL of the oral cavity.
非霍奇金淋巴瘤（NHL）通常表现为无痛性肿大淋巴结，伴有疲劳和低热间歇性发热等全身症状，主要起源于B淋巴细胞系列细胞。NHL可发生于结外部位，其中3%的病例首发部位可能在口腔。尽管口腔结外NHL较为罕见，但患有口腔NHL病变的患者通常首先就诊于牙科诊所。通过组织病理学和其他实验室检查支持的仔细临床评估，有助于早期识别该疾病，从而获得更好的预后。诊断的任何延迟都会对该病的发病率和死亡率产生重要影响。由于口腔内NHL罕见，我们在此呈现一例主诉下颌磨牙区牙龈出现肿瘤样肿物的病例。该病变临床初诊为化脓性肉芽肿，后来被诊断为口腔结外NHL。
