Department of First Medical Oncology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Shandong, China.
Oncol Res Treat. 2014;37(4):198-202. doi: 10.1159/000360779. Epub 2014 Mar 14.
Eukaryotic initiation factor 3f (eIF3f) expression, which plays an important role in human cancer, is significantly decreased in various types of cancers. The aim of this study was to detect the expression of eIF3f in gastric carcinoma (GC), which until now has not been reported.
Expression of eIF3f was detected by immunohistochemistry in GC tissues and adjacent non-cancerous tissues (ANCT) from 195 patients with stage I-III GC who underwent curative gastrectomy. Clinicopathological results, including survival, were analyzed.
Expression rate of eIF3f in GC and ANCT were 44.8 and 81.7% respectively. Low expression of eIF3f was significantly associated with an increased serum level of carcinoma embryonic antigen (p = 0.02), but not with levels of carbohydrate antigen 19-9 (p = 0.29). eIF3f levels were linked to more advanced tumor stages and likelihood of recurrence (all p < 0.05).The Kaplan-Meier survival curves indicated that decreased expression of eIF3f was a significant factor for a poor prognosis for GC patients (p = 0.04).
eIF3f may play an important role in recurrence. Its function and potential as a prognostic marker should be further verified in GC.
真核起始因子 3f (eIF3f) 的表达在人类癌症中起着重要作用，在各种类型的癌症中显著降低。本研究旨在检测胃癌（GC）中 eIF3f 的表达，迄今为止尚未有报道。
对 195 例接受根治性胃切除术的 I-III 期 GC 患者的 GC 组织和相邻非癌组织（ANCT）进行免疫组织化学检测 eIF3f 的表达。分析临床病理结果，包括生存情况。
GC 和 ANCT 中 eIF3f 的表达率分别为 44.8%和 81.7%。eIF3f 低表达与癌胚抗原（CEA）血清水平升高显著相关（p = 0.02），与碳水化合物抗原 19-9（CA19-9）水平无关（p = 0.29）。eIF3f 水平与更晚期的肿瘤分期和复发的可能性相关（均 p < 0.05）。Kaplan-Meier 生存曲线表明，eIF3f 表达降低是 GC 患者预后不良的显著因素（p = 0.04）。
eIF3f 可能在复发中起重要作用。其在 GC 中的功能和作为预后标志物的潜力应进一步验证。
