Sun Jiangang, Shi Xiaojing, Mamun M A A, Gao Yongshun
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Zhengzhou University School of Pharmaceutical Science, Zhengzhou, Henan 450001, P.R. China.
Oncol Lett. 2020 Jan;19(1):30-44. doi: 10.3892/ol.2019.11062. Epub 2019 Nov 7.
The epigenetic regulation of gene expression (via DNA methylation, histone modification and microRNA interference) contributes to a variety of diseases, particularly cancer. Protein deubiquitination serves a key role in the mechanism underlying histone modification, and consequently influences tumor development and progression. Improved characterization of the role of ubiquitinating enzymes has led to the identification of numerous deubiquitinating enzymes (DUBs) with various functions. Gastric cancer (GC) is a highly prevalent cancer type that exhibits a high mortality rate. Latest analysis about cancer patient revealed that GC is sixth deadliest cancer type, which frequently occur in male (7.2%) than female (4.1%). Complex associations between DUBs and GC progression have been revealed in multiple studies; however, the molecular mechanism underpinning the metastasis and recurrence of GC is yet to be elucidated. Generally, DUBs were upregulated in gastric cancer. The relation of DUBs and tumor size, classification and staging was observed in GC. Besides, 5-yar survival rate of patients with GC is effeccted by expression level of DUBs. Among the highly expressed DUBs, specifically six DUBs namely UCHs, USPs, OTUs, MJDs, JAMMs and MCPIPs effect on this survival rate. Consequently, the association between GC and DUBs has received increasing attention in recent years. Therefore, in the present review, literature investigating the association between DUBs and GC pathophysiology was analyzed and critically appraised.
基因表达的表观遗传调控（通过DNA甲基化、组蛋白修饰和微小RNA干扰）与多种疾病相关，尤其是癌症。蛋白质去泛素化在组蛋白修饰的潜在机制中起关键作用，进而影响肿瘤的发生和发展。对泛素化酶作用的深入了解促使人们鉴定出了众多具有不同功能的去泛素化酶（DUB）。胃癌（GC）是一种高发性癌症，死亡率很高。最新的癌症患者分析显示，GC是第六大致命癌症类型，男性的发病率（7.2%）高于女性（4.1%）。多项研究揭示了DUB与GC进展之间的复杂关联；然而，GC转移和复发的分子机制尚待阐明。一般来说，DUB在胃癌中上调。在GC中观察到了DUB与肿瘤大小、分类和分期的关系。此外，GC患者的5年生存率受DUB表达水平的影响。在高表达的DUB中，特别是六种DUB，即UCHs、USPs、OTUs、MJDs、JAMMs和MCPIPs对该生存率有影响。因此，近年来GC与DUB之间的关联受到了越来越多的关注。因此，在本综述中，对研究DUB与GC病理生理学之间关联的文献进行了分析和批判性评价。
