Gallivanone F, Canevari C, Sassi I, Zuber V, Marassi A, Gianolli L, Picchio M, Messa C, Gilardi M C, Castiglioni I
IBFM-CNR, Segrate, Milan, Italy -
Q J Nucl Med Mol Imaging. 2014 Dec;58(4):424-39. Epub 2014 Apr 15.
The aim of this paper was to assess the prognostic role of pretherapy partial volume corrected (PVC) 18F-fluorodeoxyglucose mean standardized uptake value (SUV) in breast cancer (BC).
Forty oncological patients, BC diagnosed by biopsy, with breast tumor mass diameter >1 cm measured to the mammography, designed for surgical intervention, underwent a pretherapy semi-quantitative 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) whole-body study for tumor staging. Mean Body-Weight Standardized Uptake Value with Correction for Partial Volume effect (PVC- SUVBW-mean) was calculated in all mammary detected lesions. Excised tissues from primitive BC were sectioned and classified according to the WHO guidelines, evaluating biological features. Univariate (Mann-Withney/Kruskal-Wallis) and multivariate (linear regression, hierarchical clustering) statistical tests were performed between PVC-SUVBW-mean and biological indexes. ROC analysis was performed. PVC-SUVBW-mean thresholds were derived allowing to distinguish groups of BC patients with different biological characteristics. Specificity and Sensitivity were also calculated.
Statistical and multiple correlations between pretherapy 18F-FDG PET PVC-SUVBW-mean and histological type, grade, ER/PgR hormone receptors and Mib-1 cellular proliferation index were found. In our samples, PVC-SUVBW-mean <≈4 g/cc was found correlated to BC patients with Invasive Lobular Carcinoma (ILC) or well differentiated Invasive Ductal Carcinoma (IDC), a positive expression of ER and PgR and a negative expression of MiB-1, while PVC-SUVBW-mean >≈7.00 is associated to BC patients with moderately and poorly differentiated IDC, negative expression of ER and PgR and a positive expression of MiB-1.
Pretherapy PVC 18F-FDG PET PVC-SUVBW-mean measurement correlates with prognostic factors in BC and could be used to stratify patients before intervention.
本文旨在评估治疗前部分容积校正（PVC）的18F-氟脱氧葡萄糖平均标准化摄取值（SUV）在乳腺癌（BC）中的预后作用。
40例经活检确诊为BC的肿瘤患者，乳腺肿瘤肿块直径经乳腺X线摄影测量>1 cm，计划进行手术干预，术前行治疗前半定量18F-FDG正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）全身检查以进行肿瘤分期。计算所有乳腺检测病变的平均体重标准化摄取值并校正部分容积效应（PVC-SUVBW-mean）。对原发性BC切除的组织进行切片，并根据WHO指南进行分类，评估生物学特征。在PVC-SUVBW-mean与生物学指标之间进行单变量（曼-惠特尼/克鲁斯卡尔-沃利斯）和多变量（线性回归、层次聚类）统计检验。进行ROC分析。得出PVC-SUVBW-mean阈值，以区分具有不同生物学特征的BC患者组。还计算了特异性和敏感性。
发现治疗前18F-FDG PET PVC-SUVBW-mean与组织学类型、分级、ER/PgR激素受体和Mib-1细胞增殖指数之间存在统计学和多重相关性。在我们的样本中，发现PVC-SUVBW-mean<≈4 g/cc与浸润性小叶癌（ILC）或高分化浸润性导管癌（IDC）、ER和PgR阳性表达以及MiB-1阴性表达的BC患者相关，而PVC-SUVBW-mean>≈7.00与中低分化IDC、ER和PgR阴性表达以及MiB-1阳性表达的BC患者相关。
治疗前PVC 18F-FDG PET PVC-SUVBW-mean测量值与BC的预后因素相关，可用于在干预前对患者进行分层。
